In vitro screening of traditionally used medicinal plants in China against enteroviruses

被引：38

作者：

Guo, Jin-Peng ^{[1
]}

Pang, Ji ^{[1
]}

Wang, Xin-Wei ^{[1
]}

Shen, Zhi-Qiang ^{[1
]}

Jin, Min ^{[1
]}

Li, Jun-Wen ^{[1
]}

机构：

[1] Inst Environm & Hlth, Dept Environm & Hlth, Tianjin 300050, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 25期

关键词：

traditional used medicinal plant; China; antiviral activity; enterovirus; Sargentodoxa cuneata; (Oliv) Reld. et. Wils; Sophora tonkinensis Gapnep; Paeonia veitchii Lynch; Cyrtomium fortunei J. sm; Spatholobus suberectus Dunn;

D O I：

10.3748/wjg.v12.i25.4078

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To search for new antiviral agents from traditional Chinese medicine, specifically anti-enterovirosuses agents. METHODS: The aqueous extracts (AE) of more than 100 traditionally used medicinal plants in China were evaluated for their in vitro anti-Coxsackie virus 133 activities with a MTT-based colorimetric assay. RESULTS: The test for AE of 16 plants exhibited anti-Coxsackie virus B3 activities at different magnitudes of potency. They can inhibit three steps (inactivation, adsorption and replication) during the infection. Among the 16 plants, Sargentodoxa cuneata (Oliv.) Rehd. et Wils., Sophora tonkinensis Gapnep., Paeonia veitchii Lynch, Spatholobus suberectus Dunn. and Cyrtomium fortunei J. sm. also have activity against other enterovirus, including Coxsackie virus 135, Polio virus I, Echo virus 9 and Echo virus 29. Cell cytotoxic assay demonstrated that all tested AE had CC50 values higher than their EC50 values. CONCLUSION: The sixteen traditionally used medicinal plants in. China possessed antiviral activity, and some of them merit further investigations. (C) 2006 The WJG Press. All rights reserved.

引用

页码：4078 / 4081

页数：4

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