mTOR Signaling Pathway in Cancer Targets Photodynamic Therapy In Vitro

被引：25

作者：

Ayuk, Sandra M. ^{[1
]}

Abrahamse, Heidi ^{[1
]}

机构：

[1] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, POB 17011, Doornfontein, South Africa

来源：

CELLS | 2019年 / 8卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

cancers; mTOR; inhibitors; photodynamic therapy; ADVANCED BREAST-CANCER; CLEAR-CELL CARCINOMA; MAMMALIAN TARGET; TUMOR-CELLS; PHOSPHATIDYLINOSITOL; 3-KINASES; NEUROENDOCRINE TUMORS; RAPAMYCIN AY-22,989; CLINICAL-TRIALS; DOUBLE-BLIND; PHASE-III;

D O I：

10.3390/cells8050431

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Mechanistic or Mammalian Target of Rapamycin (mTOR) is a major signaling pathway in eukaryotic cells belonging to the P13K-related kinase family of the serine/threonine protein kinase. It has been established that mTOR plays a central role in cellular processes and implicated in various cancers, diabetes, and in the aging process with very poor prognosis. Inhibition of the mTOR pathway in the cells may improve the therapeutic index in cancer treatment. Photodynamic therapy (PDT) has been established to selectively eradicate neoplasia at clearly delineated malignant lesions. This review highlights recent advances in understanding the role or regulation of mTOR in cancer therapy. It also discusses how mTOR currently contributes to cancer as well as future perspectives on targeting mTOR therapeutically in cancer in vitro.

引用

页数：15

共 130 条

[1] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[2] Photodynamic Therapy of Cancer: An Update [J].

Agostinis, Patrizia ;

Berg, Kristian ;

Cengel, Keith A. ;

Foster, Thomas H. ;

Girotti, Albert W. ;

Gollnick, Sandra O. ;

Hahn, Stephen M. ;

Hamblin, Michael R. ;

Juzeniene, Asta ;

Kessel, David ;

Korbelik, Mladen ;

Moan, Johan ;

Mroz, Pawel ;

Nowis, Dominika ;

Piette, Jacques ;

Wilson, Brian C. ;

Golab, Jakub .

CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) :250-281

[3] Synergistic effect of radachlorin mediated photodynamic therapy on propolis induced apoptosis in AMC-HN-4 cell lines via caspase dependent pathway [J].

Ahn, Jin-Chul ;

Biswas, Raktim ;

Chung, Phil-Sang .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2013, 10 (03) :236-243

[4] Photodynamic Therapy (PDT): PDT Mechanisms [J].

Allison, Ron R. ;

Moghissi, Keyvan .

CLINICAL ENDOSCOPY, 2013, 46 (01) :24-29

[5] Intracellular signaling mechanisms in photodynamic therapy [J].

Almeida, RD ;

Manadas, BJ ;

Carvalho, AP ;

Duarte, CB .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2004, 1704 (02) :59-86

[6] Clinical activity of mammalian target of rapamycin inhibitors in solid tumors [J].

Alvarado, Yesid ;

Mita, Monica M. ;

Vemulapalli, Sushma ;

Mahalingam, Devalingam ;

Mita, Alain C. .

TARGETED ONCOLOGY, 2011, 6 (02) :69-94

[7] Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial [J].

Andre, Fabrice ;

O'Regan, Ruth ;

Ozguroglu, Mustafa ;

Toi, Masakazu ;

Xu, Binghe ;

Jerusalem, Guy ;

Masuda, Norikazu ;

Wilks, Sharon ;

Arena, Francis ;

Isaacs, Claudine ;

Yap, Yoon-Sim ;

Papai, Zsuzsanna ;

Lang, Istvan ;

Armstrong, Anne ;

Lerzo, Guillermo ;

White, Michelle ;

Shen, Kunwei ;

Litton, Jennifer ;

Chen, David ;

Zhang, Yufen ;

Ali, Shyanne ;

Taran, Tetiana ;

Gianni, Luca .

LANCET ONCOLOGY, 2014, 15 (06) :580-591

[8] A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets [J].

Arsham, AM ;

Howell, JJ ;

Simon, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29655-29660

[9] STRUCTURAL BIOLOGY Architecture of human mTOR complex 1 [J].

Aylett, Christopher H. S. ;

Sauer, Evelyn ;

Imseng, Stefan ;

Boehringer, Daniel ;

Hall, Michael N. ;

Ban, Nenad ;

Maier, Timm .

SCIENCE, 2016, 351 (6268) :48-52

[10] Regulation of mTORC1 Signaling by pH [J].

Balgi, Aruna D. ;

Diering, Graham H. ;

Donohue, Elizabeth ;

Lam, Karen K. Y. ;

Fonseca, Bruno D. ;

Zimmerman, Carla ;

Numata, Masayuki ;

Roberge, Michel .

PLOS ONE, 2011, 6 (06)

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