Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

被引：10
作者：
Jimenez-Balsa, Adrian [1 ]
Pinto, Sandra [1 ,2 ]
Quartin, Emanuel [1 ,2 ]
Lino, Miguel M. [1 ,2 ]
Francisco, Vitor [1 ,2 ]
Ferreira, Lino [1 ,2 ]
机构：
[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3000 Coimbra, Portugal
[2] Univ Coimbra, Fac Med, P-3000 Coimbra, Portugal
来源：
BIOCONJUGATE CHEMISTRY | 2018年 / 29卷 / 05期
基金：
欧洲研究理事会;
关键词：
NEURAL STEM-CELLS; DRUG-DELIVERY; TRIGGERED RELEASE; MULTIPLE PROTEINS; DIFFERENTIATION; OPPORTUNITIES; DERIVATIVES; MOLECULES; LEUKEMIA; BRAIN;
D O I：
10.1021/acs.bioconjchem.7b00820
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.
引用
收藏
页码：1485 / 1489
页数：5
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  • [1] Control of Wnt/β-Catenin Signaling Pathway in Vivo via Light Responsive Capsules
    Anbrosone, Alfredo
    Marchesano, Valentina
    Carregal-Romero, Susana
    Intartaglia, Daniela
    Parak, Wolfgang J.
    Tortiglione, Claudia
    [J]. ACS NANO, 2016, 10 (04) : 4828 - 4834
  • [2] Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins
    Azagarsamy, Malar A.
    Anseth, Kristi S.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (51) : 13803 - 13807
  • [3] Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
    Boto, Carlos
    Quartin, Emanuel
    Cai, Yijun
    Martin-Lorenzo, Alberto
    Garcia Cenador, Maria Begona
    Pinto, Sandra
    Gupta, Rajeev
    Enver, Tariq
    Sanchez-Garcia, Isidro
    Hong, Dengli
    das Neves, Ricardo Pires
    Ferreira, Lino
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [4] Remotely triggered release from magnetic nanoparticles
    Derfus, Austin M.
    von Maltzahn, Geoffrey
    Harris, Todd J.
    Duza, Tasmia
    Vecchio, Kenneth S.
    Ruoslahti, Erkki
    Bhatia, Sangeeta N.
    [J]. ADVANCED MATERIALS, 2007, 19 (22) : 3932 - +
  • [5] New opportunities: The use of Nanotechnologies to manipulate and track stem cells
    Ferreira, Lino
    Karp, Jeffrey M.
    Nobre, Luis
    Langer, Robert
    [J]. CELL STEM CELL, 2008, 3 (02) : 136 - 146
  • [6] pH-Responsive Nanoparticles for Drug Delivery
    Gao, Weiwei
    Chan, Juliana M.
    Farokhzad, Omid C.
    [J]. MOLECULAR PHARMACEUTICS, 2010, 7 (06) : 1913 - 1920
  • [7] Synthesis of Photodegradable Macromers for Conjugation and Release of Bioactive Molecules
    Griffin, Donald R.
    Schlosser, Jessica L.
    Lam, Sandra F.
    Nguyen, Thi H.
    Maynard, Heather D.
    Kasko, Andrea M.
    [J]. BIOMACROMOLECULES, 2013, 14 (04) : 1199 - 1207
  • [8] Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry (vol 100, pg 2091, 2000)
    Guillier, F
    Orain, D
    Bradley, M
    [J]. CHEMICAL REVIEWS, 2000, 100 (10) : 3859 - 3859
  • [9] Photo-responsive polymeric micelles
    Huang, Yu
    Dong, Ruijiao
    Zhu, Xinyuan
    Yan, Deyue
    [J]. SOFT MATTER, 2014, 10 (33) : 6121 - 6138
  • [10] Construction of a Photoactivated Insulin Depot
    Jain, Piyush K.
    Karunakaran, Dipu
    Friedman, Simon H.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (05) : 1404 - 1409
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