Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules

被引:10
作者
Jimenez-Balsa, Adrian [1 ]
Pinto, Sandra [1 ,2 ]
Quartin, Emanuel [1 ,2 ]
Lino, Miguel M. [1 ,2 ]
Francisco, Vitor [1 ,2 ]
Ferreira, Lino [1 ,2 ]
机构
[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3000 Coimbra, Portugal
[2] Univ Coimbra, Fac Med, P-3000 Coimbra, Portugal
基金
欧洲研究理事会;
关键词
NEURAL STEM-CELLS; DRUG-DELIVERY; TRIGGERED RELEASE; MULTIPLE PROTEINS; DIFFERENTIATION; OPPORTUNITIES; DERIVATIVES; MOLECULES; LEUKEMIA; BRAIN;
D O I
10.1021/acs.bioconjchem.7b00820
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.
引用
收藏
页码:1485 / 1489
页数:5
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