Cytokine regulation of tight junctions

被引：581

作者：

Capaldo, Christopher T. ^{[1
]}

Nusrat, Asma ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Res Unit, Atlanta, GA 30322 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 04期

关键词：

Tight junction; Cytokine; IFN-gamma; TNF-alpha; Claudin; Interleukin; ZO-1; Paracellular permiability; TUMOR-NECROSIS-FACTOR; EPITHELIAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; PROTEIN-KINASE-C; BLOOD-BRAIN-BARRIER; NF-KAPPA-B; INTERFERON-GAMMA; TNF-ALPHA; INTESTINAL PERMEABILITY; PHOSPHORYLATION SITE;

D O I：

10.1016/j.bbamem.2008.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：864 / 871

页数：8

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