Cytokine regulation of tight junctions

被引：580

作者：

Capaldo, Christopher T. ^{[1
]}

Nusrat, Asma ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Res Unit, Atlanta, GA 30322 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2009年 / 1788卷 / 04期

关键词：

Tight junction; Cytokine; IFN-gamma; TNF-alpha; Claudin; Interleukin; ZO-1; Paracellular permiability; TUMOR-NECROSIS-FACTOR; EPITHELIAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; PROTEIN-KINASE-C; BLOOD-BRAIN-BARRIER; NF-KAPPA-B; INTERFERON-GAMMA; TNF-ALPHA; INTESTINAL PERMEABILITY; PHOSPHORYLATION SITE;

D O I：

10.1016/j.bbamem.2008.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：864 / 871

页数：8

共 109 条

[1]

ADAMS RB, 1993, J IMMUNOL, V150, P2356

[2] Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ [J].

Ahdieh, M ;

Vandenbos, T ;

Youakim, A .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 281 (06) :C2029-C2038

[3] IL-1β causes an increase in intestinal epithelial tight junction permeability [J].

Al-Sadi, Rana M. ;

Ma, Thomas Y. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (07) :4641-4649

[4] The role of cadherin endocytosis in endothelial barrier regulation: Involvement of protein kinase C and actin-cadherin interactions [J].

Alexander, JS ;

Jackson, SA ;

Chaney, E ;

Kevil, CG ;

Haselton, FR .

INFLAMMATION, 1998, 22 (04) :419-433

[5] Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells [J].

Amasheh, S ;

Meiri, N ;

Gitter, AH ;

Schöneberg, T ;

Mankertz, J ;

Schulzke, JD ;

Fromm, M .

JOURNAL OF CELL SCIENCE, 2002, 115 (24) :4969-4976

[6] Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines [J].

Blum, MS ;

Toninelli, E ;

Anderson, JM ;

Balda, MS ;

Zhou, JY ;

O'Donnell, L ;

Pardi, R ;

Bender, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 273 (01) :H286-H294

[7] The immunological and genetic basis of inflammatory bowel disease [J].

Bouma, G ;

Strober, W .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (07) :521-533

[8] CYTOKINES IN SYMPTOMATIC ASTHMA AIRWAYS [J].

BROIDE, DH ;

LOTZ, M ;

CUOMO, AJ ;

COBURN, DA ;

FEDERMAN, EC ;

WASSERMAN, SI .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (05) :958-967

[9] Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms [J].

Bruewer, M ;

Luegering, A ;

Kucharzik, T ;

Parkos, CA ;

Madara, JL ;

Hopkins, AM ;

Nusrat, A .

JOURNAL OF IMMUNOLOGY, 2003, 171 (11) :6164-6172

[10] Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process [J].

Bruewer, M ;

Utech, M ;

Ivanov, AI ;

Hopkins, AM ;

Parkos, CA ;

Nusrat, A .

FASEB JOURNAL, 2005, 19 (08) :923-933

← 1 2 3 4 5 6 7 8 9 10 →