Circular permutation of chicken interleukin-1 beta enhances its thermostability

被引：6

作者：

Chen, Wen-Ting ^{[1
]}

Chen, Ting ^{[1
]}

Cheng, Chao-Sheng ^{[1
]}

Huang, Wen-Yang ^{[1
]}

Wang, Xinquan ^{[2
]}

Yin, Hsien-Sheng ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu, Taiwan

[2] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 32期

关键词：

IL-1-BETA; TRANSITION; INDUCTION; SEQUENCE; IMMUNITY; STATE;

D O I：

10.1039/c3cc48313d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Interleukin-1 beta is a cytokine critically involved in immune and inflammatory responses. To extend its use as a component of avian vaccines, a circularly permuted chicken interleukin-1 beta was synthesized that maintains its activity after pre-incubation at high temperatures, unlike wild-type chicken interleukin-1 beta, which is irreversibly inactivated at high temperatures.

引用

页码：4248 / 4250

页数：3

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