Structure Elucidation at the Nanomole Scale. 2. Hemi-phorboxazole A from Phorbas sp.

被引：52

作者：

Dalisay, Doralyn S.

Molinski, Tadeusz F. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 09期

关键词：

SPONGE CALLIPELTA SP; MARINE SPONGE; ABSOLUTE-CONFIGURATION; ASYMMETRIC-SYNTHESIS; NMR-SPECTROSCOPY; SINGLET OXYGEN; (+)-PHORBOXAZOLE-A; MACROLIDES; GLYCOSIDES; SUBUNITS;

D O I：

10.1021/ol9004189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hemi-phorboxazole A, a minor truncated analogue of phorboxazole A from the marine sponge Phorbas sp., was isolated in a total yield of 16.5 mu g (28 nmol). The structure was elucidated by application of integrated nanomole-scale natural product techniques, including cryomicroprobe NMR, H-1-coupled HSQC, and circular dichroism (CD).

引用

页码：1967 / 1970

页数：4

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[1] Design, construction, and validation of a 1-mm triple-resonance high-temperature-superconducting probe for NMR [J].