TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer

被引：28
|
作者：
Guo Xiang [1 ]
Yang Yi [1 ]
He Weiwei [1 ]
Wu Weiming [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Thorac Surg, Shanghai 200233, Peoples R China
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 12期
关键词：
Nonsmall cell lung cancer; TGIF1; Beta-catenin/TCF signaling; Cell growth; Migration; SIGNALING PATHWAY; CATENIN; ADENOCARCINOMA; STATISTICS; MUTATION; GENE;
D O I：
10.1007/s13277-015-3676-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor beta-inducing factor 1 (TGIF1) was reported to be dysregulated in several types of cancer. However, its expression pattern and functions in nonsmall cell lung cancer (NSCLC) remained unknown. In the present study, the expression of TGIF1 was found to be elevated in the clinical NSCLC tissues. TGIF1 promoted the growth and migration of NSCLC cells, while knocking down the expression of TGIF1 inhibited the growth and migration of NSCLC cells. Moreover, downregulation of TGIF1 impaired the metastasis of NSCLC cells. In the study for the molecular mechanisms, it was found that TGIF1 positively regulated beta-catenin/TCF signaling. In summary, our study demonstrated the oncogenic role of TGIF1 in NSCLC, and TGIF1 might be a therapeutic target for NSCLC.
引用
收藏
页码：9303 / 9310
页数：8
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