Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

被引：13

作者：

Said, Muhammad ^{[1
,2
]}

Badshah, Amin ^{[1
]}

Shah, Naseer Ali ^{[3
]}

Khan, Hizbullah ^{[4
]}

Murtaza, Ghulam ^{[1
]}

Vabre, Boris ^{[5
]}

Zargarian, Davit ^{[5
]}

Khan, Muhammad Rashid ^{[3
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Abdul Wali Khan Univ, Dept Chem, Mardan 23200, Pakistan

[3] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan

[4] Univ Sci & Technol, Dept Chem, Bannu 28100, Pakistan

[5] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

MOLECULES | 2013年 / 18卷 / 09期

关键词：

guanidine; antitumor; antioxidant; antimicrobial assay; SPONGE MONANCHORA-UNGUIFERA; TERPENYL PYRIMIDINES; ANTILEISHMANIAL AGENTS; BIOLOGICAL-ACTIVITY; GUANIDINE DERIVATIVES; ANTIFUNGAL ACTIVITY; X-RAY; MECHANISMS; ANALOGS; ANTIBACTERIAL;

D O I：

10.3390/molecules180910378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of N-pivaloyl-N'-(alkyl/aryl)-N ''-pyridylguanidine of general formula C4H9CONHC((NRR2)-R-1) NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.

引用

页码：10378 / 10396

页数：19

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