An oligofluorene truxene based distributed feedback laser for biosensing applications

被引：27

作者：

Haughey, Anne-Marie ^{[1
]}

Guilhabert, Benoit ^{[1
]}

Kanibolotsky, Alexander L. ^{[2
]}

Skabara, Peter J. ^{[2
]}

Dawson, Martin D. ^{[1
]}

Burley, Glenn A. ^{[2
]}

Laurand, Nicolas ^{[1
]}

机构：

[1] Univ Strathclyde, SUPA, Inst Photon, Glasgow G4 0NW, Lanark, Scotland

[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

来源：

BIOSENSORS & BIOELECTRONICS | 2014年 / 54卷

基金：

英国工程与自然科学研究理事会;

关键词：

Organic; Laser; Biosensor; Oligofluorene truxene; LABEL-FREE; SILICON; PROTEIN; STREPTAVIDIN;

D O I：

10.1016/j.bios.2013.11.054

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein-small molecule interaction is reported. The protein avidin was detected down to 1 mu g mL(-1) using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to 50,000 mu g mL(-1). Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.

引用

页码：679 / 686

页数：8

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