Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma

被引：23
作者：
Naykoo, Niyaz A. [1 ]
Dil-Afroze [1 ]
Rasool, Roohi [1 ]
Shah, Sonaullah [2 ]
Ahangar, A. G. [3 ]
Bhat, Imtiyaz A. [1 ]
Qasim, Iqbal [4 ]
Siddiqi, Mushtaq A. [5 ]
Shah, Zafar A. [1 ]
机构：
[1] Sherikashmir Inst Med Sci, Dept Immunol & Mol Med, Srinagar 190011, Kashmir, India
[2] Sherikashmir Inst Med Sci, Dept Gen Med, Srinagar 190011, Kashmir, India
[3] Sherikashmir Inst Med Sci, Dept Cardio Vasc Thorac Surg, Srinagar 190011, Kashmir, India
[4] Sherikashmir Inst Med Sci, Adv Ctr Human Genet, Srinagar 190011, Kashmir, India
[5] Islamic Univ Sci & Technol Awantipora Pulwama J&K, Awantipora 192122, Jammu & Kashmir, India
来源：
GENE | 2017年 / 608卷
关键词：
VEGF; SNP; Haplotype; Expression; Lung; BREAST-CANCER; PROSTATE CARCINOMA; COLON-CANCER; ORAL-CANCER; RISK; ANGIOGENESIS; RECEPTORS; SUSCEPTIBILITY; METASTASIS; RESOLUTION;
D O I：
10.1016/j.gene.2017.01.007
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
VEGF contains several polymorphic sites known to influence its expression. We examined the possible association between + 405(-634)C > G, + 936C > T, - 2578C > A and lung cancer in 199 Kashmiri patients and 401 healthy controls. VEGF + 405CG, 936CT + TT and - 2578CA genotypes were significantly associated with lung cancer risk compared to VEGF + 405CC, + 936CC and - 2578AA + CC genotypes [OR = 0.07 (0.04 - 0.13), P < 0.0001, OR = 036 (0.25 - 0.52), P < 0.0001 and 0.08 (0.05 - 0.13), P < 0.0001]. Haplotype analysis revealed that CGA and TGA haplotypes of VEGF gene conveys the risk for lung cancer [OR = 0.18 (0.10 - 0.33), P < 0.0001 and 0.07 (0.03 - 0.13), P < 0.0001]. VEGF expression revealed non-significant association with the genotypes of the three SNPs. In conclusion, the SNPs examined appear to influence lung cancer susceptibility while as genotypes of the SNPs don't appear to have significant association with VEGF mRNA expression in lung tumours. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：95 / 102
页数：8
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