New approach in treatment of pelvic chronic pain syndrome (CPPS)

Introduction: Chronic pelvic pain syndrome (CPPS) is a complex problem that is a major cause of morbidity and disability. Objetive: To evaluate the feasibility, safety and efficacy of intravesical instillation of a new therapeutic tool in patients suffering from CPPS. Methods: Between june 2005 and september 2008 we recruited 14 patients (mean age 59) who had been diagnosed with CPPS, and refractory to previous treatments. The intravesical solution consisted of steroids, local anaesthetic, antibiotic and saline solution. Was evaluated the intensity of pain; voiding frequency and subjective improvement (with patient global improvement impression PGI-I). Results: Global pain at baseline was 6.4, at 1 month and 6 months 4.7 and 3.5. 75% of the patients showed improvement in the reduction of pain. Voiding frequency at baseline was 22'5 daily. At one and six months, voiding frequency was 16,2 and 13,5 respectively. According to the PGI-I test 30% of patients were much better, 30% moderate improvement, 10% slight improvement and 30% with no changes at I month. At 6 months, 15% of patients were much better, 40% moderated improvement, 15% slight improvement and 30% with no changes. None of the patients felt worse than before treatment. Conclusions: Therapeutic results of our intravesical solution traduces in an improvement of pain and voiding frequency reduction with no side-effects. Patients benefit of this improvement in the PGI-I test that reflects an improvement in quality of life. We consider this treatment a second-line approach for CPPS in which gold standard management is still a challenge.