Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products

被引：10
作者：
Ma, Liang [1 ,2 ]
Zhang, Wenjun [1 ,2 ]
Liu, Zhiwen [1 ,2 ]
Huang, Yanbing [1 ,3 ]
Zhang, Qingbo [1 ,2 ]
Tian, Xinpeng [1 ,2 ]
Zhang, Changsheng [1 ,2 ]
Zhu, Yiguang [1 ,2 ]
机构：
[1] Chinese Acad Sci, South China Sea Inst Oceanol, Innovat Acad South China Sea Ecol & Environm Engn, Guangdong Key Lab Marine Mat Medial,CAS Key Lab T, 164 West Xingang Rd, Guangzhou 510301, Peoples R China
[2] Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China
[3] Guangxi Acad Sci, Beibu Gulf Marine Res Ctr, Guangxi Key Lab Marine Nat Prod & Combinatorial B, Nanning 530007, Peoples R China
来源：
MARINE GENOMICS | 2021年 / 55卷
基金：
中国国家自然科学基金;
关键词：
Secondary metabolites; Biosynthetic gene cluster; Deep-sea; Piericidins; Heronamides; Bisindole alkaloids; BISINDOLE ALKALOIDS; A-E; DISCOVERY; BIOLOGY;
D O I：
10.1016/j.margen.2020.100803
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Streptomyces sp. SCSIO 03032, isolated from a deep-sea sediment sample (-3412 m) from the Indian Ocean, produces several classes of bioactive compounds including alpha-pyridone antibiotics (piericidins), polycyclic macrolactams (heronamides) and bisindole alkaloids (spiroindimicins, indimicins and lynamicins). Here we report the complete genome sequence of Streptomyces sp. SCSIO 03032, which consists of a 6,287,975 bp linear chromosome. The genome analysis reveals the presence of 29 putative biosynthetic gene clusters for secondary metabolites, including those for piericidins, heronamides and spiroindimicins/indimicins/lynamicins. The genome sequence suggests that Streptomyces sp. SCSIO 03032 could be a producer for novel bioactive natural products with potential applications in drug discovery.
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页数：4
相关论文
共 24 条
  • [1] The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters
    Blin, Kai
    Andreu, Victoria Pascal
    de los Santos, Emmanuel L. C.
    Del Carratore, Francesco
    Lee, Sang Yup
    Medema, Marnix H.
    Weber, Tilmann
    [J]. NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) : D625 - D630
  • [2] Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C
    Booth, Thomas J.
    Alt, Silke
    Capon, Robert J.
    Wilkinson, Barrie
    [J]. CHEMICAL COMMUNICATIONS, 2016, 52 (38) : 6383 - 6386
  • [3] Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis
    Chen, Yaolong
    Zhang, Wenjun
    Zhu, Yiguang
    Zhang, Qingbo
    Tian, Xinpeng
    Zhang, Si
    Zhang, Changsheng
    [J]. ORGANIC LETTERS, 2014, 16 (03) : 736 - 739
  • [4] Chin CS, 2013, NAT METHODS, V10, P563, DOI [10.1038/NMETH.2474, 10.1038/nmeth.2474]
  • [5] IslandViewer 3: more flexible, interactive genomic island discovery, visualization and analysis
    Dhillon, Bhavjinder K.
    Laird, Matthew R.
    Shay, Julie A.
    Winsor, Geoffrey L.
    Lo, Raymond
    Nizam, Fazmin
    Pereira, Sheldon K.
    Waglechner, Nicholas
    McArthur, Andrew G.
    Langille, Morgan G. I.
    Brinkman, Fiona S. L.
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (W1) : W104 - W108
  • [6] Catalytic repertoire of bacterial bisindole formation
    Du, Yi-Ling
    Ryan, Katherine S.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2016, 31 : 74 - 81
  • [7] Real-Time DNA Sequencing from Single Polymerase Molecules
    Eid, John
    Fehr, Adrian
    Gray, Jeremy
    Luong, Khai
    Lyle, John
    Otto, Geoff
    Peluso, Paul
    Rank, David
    Baybayan, Primo
    Bettman, Brad
    Bibillo, Arkadiusz
    Bjornson, Keith
    Chaudhuri, Bidhan
    Christians, Frederick
    Cicero, Ronald
    Clark, Sonya
    Dalal, Ravindra
    deWinter, Alex
    Dixon, John
    Foquet, Mathieu
    Gaertner, Alfred
    Hardenbol, Paul
    Heiner, Cheryl
    Hester, Kevin
    Holden, David
    Kearns, Gregory
    Kong, Xiangxu
    Kuse, Ronald
    Lacroix, Yves
    Lin, Steven
    Lundquist, Paul
    Ma, Congcong
    Marks, Patrick
    Maxham, Mark
    Murphy, Devon
    Park, Insil
    Pham, Thang
    Phillips, Michael
    Roy, Joy
    Sebra, Robert
    Shen, Gene
    Sorenson, Jon
    Tomaney, Austin
    Travers, Kevin
    Trulson, Mark
    Vieceli, John
    Wegener, Jeffrey
    Wu, Dawn
    Yang, Alicia
    Zaccarin, Denis
    [J]. SCIENCE, 2009, 323 (5910) : 133 - 138
  • [8] CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats
    Grissa, Ibtissem
    Vergnaud, Gilles
    Pourcel, Christine
    [J]. NUCLEIC ACIDS RESEARCH, 2007, 35 : W52 - W57
  • [9] Circos: An information aesthetic for comparative genomics
    Krzywinski, Martin
    Schein, Jacqueline
    Birol, Inanc
    Connors, Joseph
    Gascoyne, Randy
    Horsman, Doug
    Jones, Steven J.
    Marra, Marco A.
    [J]. GENOME RESEARCH, 2009, 19 (09) : 1639 - 1645
  • [10] RNAmmer:: consistent and rapid annotation of ribosomal RNA genes
    Lagesen, Karin
    Hallin, Peter
    Rodland, Einar Andreas
    Stærfeldt, Hans-Henrik
    Rognes, Torbjorn
    Ussery, David W.
    [J]. NUCLEIC ACIDS RESEARCH, 2007, 35 (09) : 3100 - 3108
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