Synthesis of Novel Substituted 1,3-diarylpropenone Derivatives and their In Vitro Cytotoxic Activity

被引：7
|
作者：
Ivanova, Yordanka [1 ]
Momekov, Georgi [2 ]
Petrov, Ognyan [1 ]
机构：
[1] Univ Sofia, Dept Appl Organ Chem, Fac Chem, Sofia 1164, Bulgaria
[2] Med Univ Sofia, Dept Pharmacol Pharmacotherapy & Toxicol, Fac Pharm, Sofia, Bulgaria
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 05期
关键词：
Chalcone; 2(3H)-benzoxazolone; Cytotoxicity; CATALYTIC-SYSTEM; MANNICH-BASES; CHALCONES; SOCL2/ETOH; AGENTS;
D O I：
10.2174/1570180810906050353
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of 6-[3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-2(3 benzoxazolone, N-alkyl derivatives and their cytotoxic activity in vitro against the human cell line BV-173 (chronic myeloid leukemia in lymphoblast crisis) are described. 3-Methyl-6-[3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]-2(3 benzoxazolone as a constitutional isomer of 3-methyl-6-[3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(3 benzoxazolone is synthesized and its influence on cytotoxic activity is investigated.
引用
收藏
页码：353 / 357
页数：5
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