A pH-SENSITIVE HYDROGEL-BASED SMART SWITCH FOR GI-TRACT PAYLOAD RELEASE

被引：0

作者：

Jiang, Hongjie ^{[1
]}

Yu, Wuyang ^{[1
]}

Zhou, Jiawei ^{[1
]}

Ziaie, Babak ^{[1
]}

机构：

[1] Purdue Univ, W Lafayette, IN 47907 USA

来源：

30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017) | 2017年

关键词：

DRUG-RELEASE; CAPSULE;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In this paper, we demonstrate a low-cost and tunable pH-triggered smart switch which is based on the deflection of a conductive elastic membrane induced by the swelling of a pH-responsive hydrogel. The described switch comprises of a porous plate, a gel chamber, a deflectable conductive membrane, and an electrical isolation cell. The switching action is initiated through a sudden pH change (e.g., transition from acidic stomach to basic small intestine) which in turn results in diffusion/time controlled hydrogel swelling, making it suitable for ingestible capsules targeted for pH-controlled localized drug release in the gastrointestinal (GI) tract. A typical prototype ( p9 mm in diameter and 3.2 mm in thickness) responds to pH changes from 2 to 7 (transition from stomach to small intestine) with a response time of one hour.

引用

页码：510 / 513

页数：4

共 15 条

[1]

BATEMAN DN, 1982, GUT, V23, P524, DOI 10.1136/gut.23.6.524

[2] Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy [J].