Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: Potential implications for pneumococcal conjugate vaccines

被引:81
作者
Rodgers, Gail L. [1 ]
Arguedas, Adriano [2 ]
Cohen, Robert [3 ]
Dagan, Ron [4 ,5 ]
机构
[1] Wyeth Pharmaceut Inc, Sci Affairs & Global Med Affairs, Collegeville, PA 19426 USA
[2] Univ Ciencias Med, Inst Atenc Pediat, San Jose, Costa Rica
[3] Ctr Hosp Intercommunal, Dept Microbiol, ACTIV, Creteil, France
[4] Soroka Univ, Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
[5] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel
关键词
Streptococcus pneumoniae; Otitis media; Serotype; MIDDLE-EAR FLUID; COSTA-RICAN CHILDREN; ANTIMICROBIAL RESISTANCE; INVASIVE DISEASE; 7-VALENT CONJUGATE; YOUNG-CHILDREN; UNITED-STATES; VACCINATION; MICROBIOLOGY; EFFICACY;
D O I
10.1016/j.vaccine.2009.04.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute otitis media (AOM) is the most common infection following pneumococcal colonization of the upper respiratory tract. Streptococcus pneumoniae causes 30-60% of AOM cases worldwide. However, not all pneumococcal serotypes cause disease and an association exists with nasopharyngeal colonization by certain serotypes and their propensity to cause AOM. This review examines the global serotype distribution relationship between pneumococcal serotypes and AOM in children aged <18 years and demonstrates that the most common pneumococcal serotypes causing AOM globally are 3, 6A, 6B, 9V, 14,19A, 19F, and 23F. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3802 / 3810
页数:9
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