The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

被引：191

作者：

Kietzmann, Thomas ^{[2
]}

Petry, Andreas ^{[1
,3
]}

Shvetsova, Antonina ^{[2
]}

Gerhold, Joachim M. ^{[4
]}

Goerlach, Agnes ^{[1
,3
]}

机构：

[1] Tech Univ Munich, German Heart Ctr Munich, Expt & Mol Pediat Cardiol, Lazarettstr 36, D-80636 Munich, Germany

[2] Univ Oulu, Fac Biochem & Mol Med, Bioctr Oulu, Oulu, Finland

[3] Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany

[4] Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 12期

基金：

芬兰科学院;

关键词：

MITOCHONDRIAL-DNA REPLICATION; DOXORUBICIN-INDUCED CARDIOTOXICITY; INDUCED CARDIAC-HYPERTROPHY; LONG NONCODING RNAS; PKC-EPSILON GENE; NF-KAPPA-B; OXIDATIVE STRESS; REDOX REGULATION; HISTONE METHYLATION; NITRIC-OXIDE;

D O I：

10.1111/bph.13792

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiovascular diseases are among the leading causes of death worldwide. Reactive oxygen species (ROS) can act as damaging molecules but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS play an important role in the pathogenesis of cardiovascular diseases, although the underlying mechanisms and consequences of pathophysiologically elevated ROS in the cardiovascular system are still not completely resolved. More recently, alterations of the epigenetic landscape, which can affect DNA methylation, post-translational histone modifications, ATP-dependent alterations to chromatin and non-coding RNA transcripts, have been considered to be of increasing importance in the pathogenesis of cardiovascular diseases. While it has long been accepted that epigenetic changes are imprinted during development or even inherited and are not changed after reaching the lineage-specific expression profile, it becomes more and more clear that epigenetic modifications are highly dynamic. Thus, they might provide an important link between the actions of ROS and cardiovascular diseases. This review will provide an overview of the role of ROS in modulating the epigenetic landscape in the context of the cardiovascular system.

引用

页码：1533 / 1554

页数：22

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