A Palladium-Catalyzed Domino Procedure for the Synthesis of Unsymmetrical Ureas

被引：45

作者：

Chen, Bo ^{[1
]}

Peng, Jin-Bao ^{[1
]}

Ying, Jun ^{[1
]}

Qi, Xinxin ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Zhejiang, Peoples R China

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 15期

关键词：

Cascade reaction; Unsymmetrical urea; Carbonylation; Curtius rearrangement; Palladium catalyst; OXIDATIVE CARBONYLATION; REDUCTIVE CARBONYLATION; ONE-POT; AROMATIC AZIDOCARBONYLATION; ASYMMETRIC CATALYSIS; SMALL-MOLECULE; AMINES; DERIVATIVES; SELENIUM; CO;

D O I：

10.1002/adsc.201800496

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A palladium-catalyzed carbonylative procedure for the synthesis of unsymmetrical ureas has been developed. This one-pot one-step cascade procedure is consisted by three individual processes: carbonylation, Curtius rearrangement, and nucleophilic addition. A series of unsymmetrical ureas were prepared from easily available aryl iodides and amines in moderate to excellent yields. This procedure provides a convenient and practical approach for unsymmetrical urea synthesis.

引用

页码：2820 / 2824

页数：5

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