Acylated iridoid glucosides from Pseudocaryopteris paniculata (CB Clarke) PDCantino

被引：3
作者：
Xu, Hong-Tao [1 ,2 ]
Chen, Yi [1 ,2 ]
Zhang, Cheng-Gang [1 ,2 ]
Ju, Zheng-Cai [1 ,2 ]
Wang, Yong-Li [1 ,2 ]
Chou, Gui-Xin [1 ,2 ,3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med SHUTCM, Inst Chinese Mat Med ICMM, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med SHUTCM, Inst Chinese Mat Med ICMM, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China
[3] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China
来源：
PHYTOCHEMISTRY | 2021年 / 181卷
基金：
中国国家自然科学基金;
关键词：
Pseudocaryopteris paniculata (CBClarke) PD; Cantino; Lamiaceae; NMR spectroscopy; Iridoid glucosides; Paniculosides a-Z; Cytoprotective activity;
D O I：
10.1016/j.phytochem.2020.112569
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phytochemical investigation of the ethyl acetate fraction of Pseudocaryopteris paniculata C.B.Clarke P.D.Cantino resulted in the identification of 26 undescribed iridoid glucosides (paniculosides A-Z), along with 7 known iridoid glucosides. Their structures were elucidated via two-dimensional nuclear-magnetic-resonance (2D-NMR) spectroscopy, high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS), and chemical-hydrolysis methods. All isolated substances were analyzed for their cytoprotective effects against t-BHP-induced toxicity in HepG2 cells. Among the tested compounds, paniculoside A, paniculoside I, paniculoside T, and paniculoside U exhibited moderate cytoprotective activities with IC50 values in the range of 11.72-34.22 mu M against t-BHP-induced toxicity.
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页数：11
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