Allogeneic stem cell transplantation in poor prognosis peripheral T-cell lymphoma: the impact of different donor type on outcome

被引：10

作者：

Castagna, Luca ^{[1
]}

Pagliardini, Thomas ^{[2
]}

Bramanti, Stefania ^{[1
]}

Schiano de Colella, Jean Marc ^{[2
]}

Montes de Oca, Catalina ^{[2
]}

Bouabdallah, Reda ^{[2
]}

Mariotti, Jacopo ^{[1
]}

Furst, Sabine ^{[2
]}

Granata, Angela ^{[2
]}

De Philippis, Chiara ^{[1
]}

Harbi, Samia ^{[2
]}

Sarina, Barbara ^{[1
]}

Legrand, Faezeh ^{[2
]}

Maisano, Valerio ^{[2
]}

Weiller, Pierre Jean ^{[2
]}

Chabannon, Christian ^{[3
]}

Carlo-Stella, Carmelo ^{[1
,4
]}

Santoro, Armando ^{[1
,4
]}

Blaise, Didier ^{[2
]}

Devillier, Raynier ^{[2
]}

机构：

[1] IRCCS, Humanitas Clin & Res Ctr, Via Manzoni 56, I-20089 Milan, Italy

[2] Aix Marseille Univ, Inst Paoli Calmettes, Dept Haematol, Marseille, France

[3] Aix Marseille Univ, INSERM CBT 1409, Inst Paoli Calmettes, Ctr Clin Invest Biotherapy, Marseille, France

[4] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20090 Milan, Italy

来源：

BONE MARROW TRANSPLANTATION | 2021年 / 56卷 / 04期

关键词：

NON-HODGKIN-LYMPHOMA; BONE-MARROW-TRANSPLANTATION; LONG-TERM REMISSIONS; REDUCED-INTENSITY; HAPLOIDENTICAL TRANSPLANTATION; EUROPEAN-SOCIETY; WORKING PARTY; BLOOD; CYCLOPHOSPHAMIDE; DISEASE;

D O I：

10.1038/s41409-020-01133-5

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report the outcome of 68 patients with advanced peripheral T-cell lymphoma receiving transplantation from haploidentical or from conventional donors. The 4-year OS, PFS, 2-year cumulative incidence of relapse and 2-year GRFS was 75%, 70%, 21%, and 51%, respectively. Survival was not affected by donor type. The 2-year NRM was 9%, lower after related or haploidentical donor (21% vs 0% vs 7%; p = 0.06). Grade 2-4 aGVHD cumulative incidence was significantly different after transplantation from haploidentical vs matched sibling vs unrelated donor, and (24% vs 35% vs 58%, p = 0.024). The familial donor cohort was compared to the unrelated cohort. Familial donor induced less grade 2-4 aGVHD, with a trend to less grade 3-4 aGVHD or moderate-severe cGVHD. The OS and PFS were not different, while the relapse risk and NRM were reduced. Allo-SCT is highly effective in T-cell lymphoma, with low NRM and low relapse rate. The incidence of aGVHD was lower after haploidentical transplantation. Related donor may challenge unrelated transplant reducing the risk of relapse and NRM.

引用

页码：883 / 889

页数：7

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