In vitro anti-oxidant potential of new metabolites from Hypericum oblongifolium (Guttiferae)

被引:13
作者
Raziq, Naila [1 ,2 ]
Saeed, Muhammad [1 ]
Ali, Muhammad Shaiq [3 ]
Zafar, Salman [4 ]
Ali, Muhammad Imran [3 ,5 ]
机构
[1] Univ Peshawar, Dept Pharm, Peshawar 25120, Pakistan
[2] Sarhad Univ Sci & Informat Technol, Dept Pharm, Peshawar, Pakistan
[3] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[4] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan
[5] Govt Degree Boys Coll, Karachi, Pakistan
关键词
Hypericum oblongifolium; Guttiferae; folicitin; folenolide; flavone; antioxidant; FLAVONOIDS;
D O I
10.1080/14786419.2015.1009064
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Phytochemical investigations on Hypericum oblongifolium led to the isolation of a flavone named folicitin (1) and a bicyclic conjugated lactone, folenolide (2) from the ethyl acetate fraction of methanolic extract. Both metabolites were characterised as new compounds based on detailed spectroscopic analyses. In vitro anti-oxidant potential of both the compounds was evaluated by the DPPH radical scavenging assay. Compound 1 exhibited significant antioxidant activity while compound 2 was found inactive.
引用
收藏
页码:2265 / 2270
页数:6
相关论文
共 22 条
[1]  
Ali M, 2011, J CHEM SOC PAKISTAN, V33, P772
[2]   Anti-Inflammatory Xanthones from the Twigs of Hypericum oblongifolium Wall. [J].
Ali, Mumtaz ;
Arfan, Muhammad ;
Ahmad, Manzoor ;
Singh, Kuldip ;
Anis, Itrat ;
Ahmad, Habib ;
Choudhary, Muhammad Iqbal ;
Shah, Muhammad Raza .
PLANTA MEDICA, 2011, 77 (18) :2013-2018
[3]   Urease inhibitors from Hypericum oblongifolium WALL. [J].
Arfan, Mohammad ;
Ali, Mumtaz ;
Ahmad, Habib ;
Anis, Itrat ;
Khan, Ajmal ;
Choudhary, M. Iqbal ;
Shah, Muhammad Raza .
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2010, 25 (02) :296-299
[4]  
Bernardi APM, 2007, J CHIL CHEM SOC, V52, P1326, DOI 10.4067/S0717-97072007000400013
[5]   Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation [J].
Cakir, A ;
Mavi, A ;
Yildirim, A ;
Duru, ME ;
Harmandar, H ;
Kazaz, C .
JOURNAL OF ETHNOPHARMACOLOGY, 2003, 87 (01) :73-83
[6]   Antibacterial activity of the endemic Hypericum kazdaghensis [J].
Dulger, B ;
Gonuz, A .
FITOTERAPIA, 2005, 76 (02) :237-239
[7]   THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].
ESTERBAUER, H ;
GEBICKI, J ;
PUHL, H ;
JURGENS, G .
FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390
[8]  
Ferheen S, 2005, J CHEM SOC PAKISTAN, V27, P533
[9]   Hyperinols A and B, chymotrypsin inhibiting triterpenes from Hypericum oblongifolium [J].
Ferheen, Sadia ;
Ahmed, Ejaz ;
Malik, Abdul ;
Afza, Nighat ;
Lodhi, Muhammad Arif ;
Choudhary, Muhammad Iqbal .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (08) :1088-1090
[10]  
Ghulam Abbas Ghulam Abbas, 2013, International Journal of Phytomedicine, V5, P191