Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species

被引：7

作者：

Gomez, Analia A. ^{[1
]}

Teran Baptista, Zareath P. ^{[1
]}

Mandova, Tsvetelina ^{[2
,3
]}

Barouti, Angeliki ^{[2
]}

Kritsanida, Marina ^{[2
]}

Grougnet, Raphael ^{[2
]}

Vattuone, Marta A. ^{[1
]}

Sampietro, Diego A. ^{[1
]}

机构：

[1] Univ Nacl Tucuman, LABIFITO, Fac Bioquim Quim & Farm, San Miguel De Tucuman, Tucuman, Argentina

[2] Univ Paris 05, Lab Pharmacognosie, Sorbonne Paris Cite, Fac Pharm Paris,UMR CNRS 8638 COMETE, Paris, France

[3] Gilson Purificat SAS, St Ave, France

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 22期

关键词：

Alkaloids; antifungal; antiaflatoxigenic; Aspergillus; Prosopis; GROWTH;

D O I：

10.1080/14786419.2018.1560286

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Extracts from aerial parts of Prosopis ruscifolia, Bidens pilosa, Cercidium praecox and Phoradendron liga were assayed against toxigenic Aspergillus species. They were obtained by sequential extraction of the aerial parts with hexane (fHex), dichloromethane (fDCM), ethyl acetate (fEtOAc) and methanol (fMeOH). The fMeOH from P. ruscifolia showed the highest antifungal spectrum (MIC = 750-1500 mu g mL(-1); MID = 50-200 mu g; DI = 1.7-3.0 mm). Indolizidine alkaloids (juliflorine and juliprosine) and tryptamine were identified with strong (MIC = 188 mu g mL(-1)) and moderate antifungal activities (MIC = 750 mu g mL(-1)), respectively, towards A. parasiticus and A. flavus. The fMeOH, the indolizidine alkaloids and tryptamine synergized the fungitoxic effect of potassium sorbate and propiconazole. They completely suppressed the biosynthesis of aflatoxins at concentrations of 47, 94 and 375 mu g mL(-1), respectively. Our results indicate that fMeOH and its identified alkaloids are promisory additives of commercial antifungals and are antiaflatoxigenic agents at concentrations below of those required for complete suppression of fungal growth.

引用

页码：3299 / 3302

页数：4

共 7 条

[1] Control of Aspergillus section Flavi growth and aflatoxin accumulation by plant essential oils [J].