Synthesis of novel and non-natural ceramide analogues derived from L-glutamic acid

被引：15
|
作者：
Shikata, K [1 ]
Azuma, H [1 ]
Tachibana, T [1 ]
Ogino, K [1 ]
机构：
[1] Osaka City Univ, Grad Sch Engn, Dept Bioappl Chem, Sumiyoshi Ku, Osaka 5588585, Japan
来源：
TETRAHEDRON | 2002年 / 58卷 / 29期
关键词：
ceramide; glutamic acid; sphingolipids;
D O I：
10.1016/S0040-4020(02)00558-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel and non-natural ceramide analogues, having a different methylene spacer between the primary hydroxymethyl group and aminomethane of sphingosine backbone, have been prepared from L-glutamic acid. The key step in the preparation is the diastereoselective reduction of an enone adjacent to a Boc protected amino group by reducing agents. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5803 / 5809
页数：7
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