Synthesis and DNA binding properties of dioxime-peptide nucleic acids

被引：20

作者：

Mokhir, A

Krämer, R

Voloshin, YZ

Varzatskii, OA

机构：

[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany

[2] LY Karpov Phys Chem Res Inst, Moscow 105064, Russia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 11期

关键词：

peptide nucleic acids; oxime; conjugate;

D O I：

10.1016/j.bmcl.2004.03.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptide nucleic acids (PNAs) C- or N-modified with dioxime ligands were prepared by solid-phase synthesis using iron(II)-clathrochelates as protected dioxime building blocks. These PNA bind complementary DNA sequence specifically, though with much reduced affinity in comparison with nonmodified PNA. The dioxime-PNA conjugates bind Cu2+ and Ni2+ at PM concentration. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2927 / 2930

页数：4

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