Atypical transforming growth factor-β signaling in the hypothalamus is linked to diabetes

被引：13

作者：

Araujo, Eliana P. ^{[1
]}

de Souza, Claudio T. ^{[2
]}

Velloso, Licio A. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Lab Cell Signaling, Campinas, SP, Brazil

[2] Univ Sul Catarinense UNESC, Lab Exercise Biochem & Physiol, Crisciuma, Brazil

来源：

NATURE MEDICINE | 2014年 / 20卷 / 09期

关键词：

STRESS GRANULES; KAPPA-B; SYSTEM;

D O I：

10.1038/nm.3673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-beta 1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.

引用

页码：985 / 987

页数：3

共 15 条

[1] Targeting the TGFβ signalling pathway in disease [J].

Akhurst, Rosemary J. ;

Hata, Akiko .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (10) :790-811

[2] Stress granules: The Tao of RNA triage [J].

Anderson, Paul ;

Kedersha, Nancy .

TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (03) :141-150

[3] Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus [J].

De Souza, CT ;

Araujo, EP ;

Bordin, S ;

Ashimine, R ;

Zollner, RL ;

Boschero, AC ;

Saad, MJA ;

Velloso, LA .

ENDOCRINOLOGY, 2005, 146 (10) :4192-4199

[4] Transforming Growth Factor-β1 and Incident Type 2 Diabetes Results from the MONICA/KORA case-cohort study, 1984-2002 [J].

Herder, Christian ;

Zierer, Astrid ;

Koenig, Wolfgang ;

Roden, Michael ;

Meisinger, Christa ;

Thorand, Barbara .

DIABETES CARE, 2009, 32 (10) :1921-1923

[5] Defective Regulation of the Ubiquitin/Proteasome System in the Hypothalamus of Obese Male Mice [J].

Ignacio-Souza, Leticia M. ;

Bombassaro, Bruna ;

Pascoal, Livia B. ;

Portovedo, Mariana A. ;

Razolli, Daniela S. ;

Coope, Andressa ;

Victorio, Sheila C. ;

de Moura, Rodrigo F. ;

Nascimento, Lucas F. ;

Arruda, Ana P. ;

Anhe, Gabriel F. ;

Milanski, Marciane ;

Velloso, Licio A. .

ENDOCRINOLOGY, 2014, 155 (08) :2831-2844

[6] CNS Regulation of Glucose Homeostasis [J].

Lam, Carol K. L. ;

Chari, Madhu ;

Lam, Tony K. T. .

PHYSIOLOGY, 2009, 24 (03) :159-170

[7] Inhibition of the ubiquitin-proteasome system induces stress granule formation [J].

Mazroui, Rachid ;

Di Marco, Sergio ;

Kaufman, Randal J. ;

Gallouzi, Imed-Eddine .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (07) :2603-2618

[8] TARGETED DISRUPTION OF THE MOUSE TRANSFORMING GROWTH FACTOR-BETA-1 GENE RESULTS IN MULTIFOCAL INFLAMMATORY DISEASE [J].

SHULL, MM ;

ORMSBY, I ;

KIER, AB ;

PAWLOWSKI, S ;

DIEBOLD, RJ ;

YIN, MY ;

ALLEN, R ;

SIDMAN, C ;

PROETZEL, G ;

CALVIN, D ;

ANNUNZIATA, N ;

DOETSCHMAN, T .

NATURE, 1992, 359 (6397) :693-699

[9] Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production [J].

Takahashi, Masahiko ;

Higuchi, Masaya ;

Matsuki, Hideaki ;

Yoshita, Manami ;

Ohsawa, Toshiaki ;

Oie, Masayasu ;

Fujii, Masahiro .

MOLECULAR AND CELLULAR BIOLOGY, 2013, 33 (04) :815-829

[10] 'Yin-Yang' functions of transforming growth factor-β and T regulatory cells in immune regulation [J].

Wan, Yisong Y. ;

Flavell, Richard A. .

IMMUNOLOGICAL REVIEWS, 2007, 220 :199-213

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