Facile synthesis of imidazo[1,2-a]pyridines via a one-pot three-component reaction under solvent-free mechanochemical ball-milling conditions

被引：24

作者：

Maleki, Ali ^{[1
]}

Javanshir, Shahrzad ^{[1
]}

Naimabadi, Maryam ^{[1
]}

机构：

[1] Iran Univ Sci & Technol, Dept Chem, Tehran 1684613114, Iran

来源：

RSC ADVANCES | 2014年 / 4卷 / 57期

基金：

美国国家科学基金会;

关键词：

MULTICOMPONENT REACTIONS; 2-AMINOPYRIDINES; DERIVATIVES; ALDEHYDES; PYRIDINES; CATALYST;

D O I：

10.1039/c3ra43221a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, 3-aminoimidazo[1,2-a]pyridine derivatives have been synthesized by a one-pot three-component condensation reaction of 2-aminopridines, aldehydes and isocyanides under solvent-free mechanochemical ball-milling conditions in good to excellent yields at room temperature. This efficient protocol has many noticeable advantages such as mild reaction conditions, high yields, high atom economy, short reaction times and simple separation.

引用

页码：30229 / 30232

页数：4

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