Non-coding-RNA regulators of RNA polymerase II transcription

被引:194
作者
Goodrich, James A. [1 ]
Kugel, Jennifer F. [1 ]
机构
[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1038/nrm1946
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are extremely diverse, which indicates that, so far, we have only had a glimpse of this new class of regulatory factor. Many surprises are likely to be revealed as further ncRNA transcriptional regulators are identified and characterized.
引用
收藏
页码:612 / 616
页数:5
相关论文
共 40 条
[1]   The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock [J].
Allen, TA ;
Von Kaenel, S ;
Goodrich, JA ;
Kugel, JF .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (09) :816-821
[2]   RNA silencing and genome regulation [J].
Almeida, R ;
Allshire, RC .
TRENDS IN CELL BIOLOGY, 2005, 15 (05) :251-258
[3]  
Boumil RM, 2001, HUM MOL GENET, V10, P2225
[4]   B2 RNA binds directly to RNA polymerase II to repress transcript synthesis [J].
Espinoza, CA ;
Allen, TA ;
Hieb, AR ;
Kugel, JF ;
Goodrich, JA .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (09) :822-829
[5]   Distinct transcriptional responses of RNA polymerases I, II and III to aptamers that bind TBP [J].
Fan, XC ;
Shi, H ;
Lis, JT .
NUCLEIC ACIDS RESEARCH, 2005, 33 (03) :838-845
[6]   Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes [J].
Fan, XC ;
Shi, H ;
Adelman, K ;
List, JT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (18) :6934-6939
[7]   HIV-1 TAT TRANS-ACTIVATION REQUIRES THE LOOP SEQUENCE WITHIN TAR [J].
FENG, S ;
HOLLAND, EC .
NATURE, 1988, 334 (6178) :165-167
[8]   Molecular mimicry of the NF-κB DNA target site by a selected RNA aptamer [J].
Ghosh, G ;
Huang, DB ;
Huxford, T .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (01) :21-27
[9]   Transcription attenuation [J].
Gollnick, P ;
Babitzke, P .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2002, 1577 (02) :240-250
[10]   Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors [J].
Kadonaga, JT .
CELL, 2004, 116 (02) :247-257