Role of Post-Translational Modifications of cGAS in Innate Immunity

被引：31

作者：

Wu, Yakun ^{[1
]}

Li, Shitao ^{[1
]}

机构：

[1] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 21期

基金：

美国国家卫生研究院;

关键词：

cGAS; innate immunity; post-translational modification; phosphorylation; ubiquitination; acetylation; glutamylation; sumoylation; DNA SENSOR CGAS; CYCLIC GMP-AMP; STRUCTURAL BASIS; 2ND-MESSENGER; PROMOTES; SYNTHASE; FAMILY; CONSEQUENCES; DINUCLEOTIDE; ACETYLATION;

D O I：

10.3390/ijms21217842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic GMP-AMP synthase (cGAS) is the synthase that generates the second messenger cyclic GMP-AMP (cGAMP) upon DNA binding. cGAS was first discovered as the cytosolic DNA sensor that detects DNA exposed in the cytoplasm either from pathogens or cellular damage. Activated cGAS instigates the signaling cascades to activate type I interferon (IFN) expression, critical for host defense and autoimmune diseases. In addition, cGAS plays a role in senescence, DNA repair, apoptosis, and tumorigenesis. Recently, various post-translational modifications (PTMs) of cGAS have been reported, such as phosphorylation, ubiquitination, acetylation, glutamylation, and sumoylation. These PTMs profoundly affect cGAS functions. Thus, here we review the recent reported PTMs of cGAS and how these PTMs regulate cGAS enzymatic activity, DNA binding, and protein stability, and discuss the potential future directions.

引用

页码：1 / 13

页数：13

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