Clonality analysis of T cells mediating acute and chronic rejection in kidney allografts

被引：10
作者：
Obata, F
Yoshida, K
Ikeda, Y
Ohkubo, M
Saito, T
Takeuchi, Y
Shinohara, N
Endo, T
Baba, S
机构：
[1] Kitasato Univ, Sch Allied Hlth Sci, Div Immunol, Sagamihara, Kanagawa 2288555, Japan
[2] Kitasato Univ, Sch Med, Dept Urol, Sagamihara, Kanagawa 2288555, Japan
[3] Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 2288555, Japan
[4] Saitama Ken O Hosp, Dept Urol, Okegawa, Saitama 3630008, Japan
来源：
TRANSPLANT IMMUNOLOGY | 2004年 / 13卷 / 03期
关键词：
acute rejection; chronic rejection; kidney; transplantation; T-cell clonality;
D O I：
10.1016/j.trim.2004.04.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The clonality of T-cell populations mediating acute and chronic rejection (AR and CR, respectively) of kidney allografts was ascertained by investigating the diversity of TCRBV genes expressed by allograft-infiltrating T cells. Both oligoclonality and polyclonality cases were found in biopsy specimens of AR as well as CR. These results indicated that the T-cell clonality in each specimen did not correlate directly with the mode of rejection. When AR and CR specimens were compared, however, the CR specimen group was significantly more polyclonal (or less oligoclonal) than the AR group. This result may reflect the higher chance of epitope spreading in the more slowly progressing CR than in AR. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：233 / 237
页数：5
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