Hydrogels Based on Schiff Base Linkages for Biomedical Applications

被引：398

作者：

Xu, Junpeng ^{[1
]}

Liu, Yi ^{[1
]}

Hsu, Shan-hui ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Inst Polymer Sci & Engn, 1,Sec 4 Roosevelt Rd, Taipei 10617, Taiwan

[2] Natl Hlth Res Inst, Inst Cellular & Syst Med, 35 Keyan Rd, Miaoli 35053, Taiwan

来源：

MOLECULES | 2019年 / 24卷 / 16期

关键词：

Schiff base; hydrogel; click chemistry; self-healing; dynamic covalent bond; tissue engineering; SELF-HEALING HYDROGEL; CHITOSAN-BASED HYDROGELS; ACID-BASED HYDROGELS; SITU CROSS-LINKING; INJECTABLE HYDROGELS; CLICK CHEMISTRY; HYALURONIC-ACID; COMPOSITE HYDROGEL; ADHESIVE; POLYMER;

D O I：

10.3390/molecules24163005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors.

引用

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