At the Heart of Bacterial Cytokinesis: The Z Ring

被引：96

作者：

Du, Shishen ^{[1
]}

Lutkenhaus, Joe ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Microbiol Mol Genet & Immunol, Kansas City, KS 66160 USA

来源：

TRENDS IN MICROBIOLOGY | 2019年 / 27卷 / 09期

关键词：

CELL-DIVISION PROTEIN; ESCHERICHIA-COLI-FTSZ; TUBULIN-LIKE PROTEIN; C-TERMINAL LINKER; ANALYSES REVEAL; GTPASE ACTIVITY; GENE ZIPA; FILAMENTS; MEMBRANE; BINDING;

D O I：

10.1016/j.tim.2019.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial cell division is mediated by the divisome which is organized by the Z ring, a cytoskeletal element formed by the polymerization of the tubulin homologue FtsZ. Despite billions of years of bacterial evolution, the Z ring is nearly universal among bacteria that have a cell wall and divide by binary fission. Recent studies have revealed the mechanism of cooperative assembly of FtsZ and that the Z ring consists of patches of FtsZ filaments tethered to the membrane that treadmill to distribute the septal biosynthetic machinery. Here, we summarize these advances and discuss questions raised by these new findings.

引用

页码：781 / 791

页数：11

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