Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

被引：16
|
作者：
Vanin, Anatoly F. [1 ,2 ]
Tronov, Viktor A. [1 ]
Borodulin, Rostislav R. [1 ]
机构：
[1] Russian Acad Sci, Semenov Fed Res Ctr Chem Phys, Moscow, Russia
[2] Sechenov Med Univ, Inst Regenerat Med, Moscow, Russia
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2021年 / 79卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
Dinitrosyl iron complexes; Nitric oxide; Nitrosonium cations; Apoptosis; NITRIC-OXIDE; NO; GLUTATHIONE; DECOMPOSITION; NITROSATION; INHIBITION; MECHANISMS; APOPTOSIS; KINETICS; DELIVERY;
D O I：
10.1007/s12013-020-00962-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we demonstrate that binuclear dinitrosyl iron complexes with thiol-containing ligands (glutathione and mercaptosuccinate, B-DNIC-GSH and B-DNIC-MS, respectively) exert cytotoxic effects on MCF7 human breast cancer cells. We showed that they are mediated by nitrosonium cations released from these complexes (NO+). This finding is supported by the cytotoxic effect of both B-DNICs on MCF7 cells evidenced to retain or was even promoted in the presence of N-Methyl-D-glucamine dithiocarbamate (MGD). MGD recruits an iron nitrosyl group [Fe(NO)] from the iron-dinitrosyl fragment [Fe(NO)(2)] of B-DNIC-MS forming stable mononitrosyl complexes of iron with MGD and releasing NO+ cations from a [Fe(NO)(2)] fragment.
引用
收藏
页码：93 / 102
页数：10
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