A Copper-Catalyzed Domino Reaction of Alkynyl Bromides and Oxazolidine-2-thiones: Synthesis of Thiazol-2-ones

被引：1
作者：
Xie, Chunsong [1 ]
Zhang, Yuhong [2 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 05期
关键词：
alkynyl bromide; copper catalysis; domino reaction; oxazolidine-2-thione; thiazol-2-one; CROSS-COUPLING REACTIONS; ARYL BOND FORMATION; C-C; PALLADIUM; YNAMIDES; ACID; ARYLATION; HETEROCYCLES; CYCLIZATIONS; AMIDATIONS;
D O I：
10.1002/ajoc.201800154
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed cyclization of alkynyl bromides and oxazolidine-2-thiones is described. C- N and C-S bonds are simultaneously constructed and a multi-step process occurred to give the five-member heterocycles of thiazol-2-ones containing 2-alkylthio-oxazolines. Optically active oxazolidine-2-thiones undergo the cyclization with complete retention of configuration.
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收藏
页码：888 / 891
页数：4
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