Genetic susceptibilities and prediction modeling of carbamazepine and allopurinol-induced severe cutaneous adverse reactions in Vietnamese

被引：15

作者：

Dinh van Nguyen ^{[1
,2
,3
,4
]}

Hieu Chi Chu ^{[5
]}

Vidal, Christopher ^{[3
]}

Fulton, Richard B. ^{[4
]}

Nguyet Nhu Nguyen ^{[5
]}

Nga Thi Quynh ^{[6
]}

Tu Linh Tran ^{[7
]}

Thuy Ninh Nguyen ^{[7
]}

Ha Thi Thu Nguyen ^{[8
]}

Hanh Hong Chu ^{[9
]}

Huyen Thi Thanh Thuc ^{[9
]}

Huong Thi Minh Le ^{[9
]}

van Nunen, Sheryl ^{[3
,10
]}

Anderson, Janet ^{[4
]}

Fernando, Suran L. ^{[3
,4
,10
]}

机构：

[1] Vinmec Healthcare Syst, Hanoi 100000, Vietnam

[2] VinUniversity, Coll Hlth Sci, Hanoi 100000, Vietnam

[3] Univ Sydney, Sydney Med Sch Northern, Sydney, NSW 2065, Australia

[4] Royal North Shore Hosp, ImmunoRheumatol Lab, NSW Hlth Pathol North, Sydney, NSW 2065, Australia

[5] Bach Mai Hosp, Ctr Allergol & Clin Immunol, Hanoi 115000, Vietnam

[6] Natl Inst Hyg & Epidemiol, Dept Immunol & Mol Biol, Hanoi 100000, Vietnam

[7] Hanoi Heart Hosp, Hanoi 100000, Vietnam

[8] Hanoi Med Univ, Dept Allergy & Clin Immunol, Hanoi 100000, Vietnam

[9] Natl Hosp Pediat, Dept Allergy Immunol & Rheumatol, Hanoi 100000, Vietnam

[10] Royal North Shore Hosp, Dept Clin Immunol & Allergy, Sydney, NSW 2065, Australia

来源：

PHARMACOGENOMICS | 2021年 / 22卷 / 01期

关键词：

allopurinol; carbamazepine; DRESS; HLA; severe cutaneous adverse drug reactions; S[!text type='JS']JS[!/text; TEN; Vietnamese; TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON-SYNDROME; INDUCED HYPERSENSITIVITY REACTIONS; HLA-B-ASTERISK-1502; ALLELE; ANTIEPILEPTIC DRUGS; RURAL DISTRICT; ASSOCIATION; EPILEPSY; POPULATION; OXYPURINOL;

D O I：

10.2217/pgs-2019-0146

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims: To determine genetic susceptibility markers for carbamazepine (CBZ) and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese. Methods: A case control study was performed involving 122 patients with CBZ or allopurinol induced SCARs and 120 drug tolerant controls. Results: HLA-B*58:01 was strongly associated with allopurinol-induced SCARs and strongly correlated with SNP rs9263726. HLA-B*15:02 was associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis but not with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. No association was found between HLA-A*31:01 and CBZ-induced SCARs. HLA-B*58:01 and rs3909184 allele A with renal insufficiency were shown to increase the risk of allopurinol-induced SCARs. Conclusion: HLA-B*58:01 and HLA-B*15:02 confer susceptibility to allopurinol-induced SCARs and CBZ-induced SJS/TEN in Vietnamese. Single nucleotide polymorphism rs9263726 can be used as a surrogate marker in identifying HLA-B*58:01.

引用

页码：1 / 12

页数：12

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