Antibacterial and Solubility Analysis of Experimental Phytotherapeutic Paste for Endodontic Treatment of Primary Teeth

被引:4
作者
Freire, Aldelany Ramalho [1 ]
Wanderley Gomes Freire, Deborah Ellen [1 ]
de Sousa, Simone Alves [2 ]
Serpa, Eliane Medeiros [2 ]
Dantas de Almeida, Leopoldina de Fatima [2 ]
Cavalcanti, Yuri Wanderley [2 ]
机构
[1] Univ Fed Paraiba, Sch Dent, Grad Program Dent, Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, Sch Dent, Dept Clin & Social Dent, Joao Pessoa, Paraiba, Brazil
来源
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA | 2021年 / 21卷
关键词
Root Canal Filling Materials; Tooth; Deciduous; Plant Extracts; Enterococcus faecalis; ENTEROCOCCUS-FAECALIS; ANTIMICROBIAL ACTIVITY; DEVELOPMENTAL DEFECTS; PLANT-EXTRACTS; FILLING PASTES; ESSENTIAL OILS; DENTAL-CARIES; CINNAMALDEHYDE; EFFICACY; THYMOL;
D O I
10.1590/pboci.2021.005
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective: To evaluate the antibacterial effect and the solubility of experimental root canal filling pastes containing the phytoconstituents terpineol and cinnamaldehyde. Material and Methods: Minimum Inhibitory Concentration (MIC) of each phytoconstituent was determined against Enterococcus faecalis. Five groups of antibiotic pastes based on zinc oxide were obtained by mixing: only terpineol, only cinnamaldehyde, terpineol and cinnamaldehyde combined, chlorhexidine (antibiotic control), and CTZ paste (control paste). Antibacterial activity was analyzed through direct contact test within 24 and 72 hours. Solubility was evaluated by spectrophotometry within 48 and 144 hours. Antibacterial activity data were analyzed descriptively, and solubility data was analyzed using ANOVA and Tukey tests (p<0.05). Results: The MIC obtained for terpineol and cinnamaldehyde were, respectively, 2000 mu g/mL and 500 mu g/mL. After 24h, only the terpineol paste did not inhibit E. faecalis growth. After 72h, all groups inhibited E. faecalis growth. After 48h, the highest solubility was verified in the terpineol paste (p<0.05), and no differences were detected among other groups (p>0.05). After and 144h, highest solubility was observed in the terpineol paste (p<0.05), followed by the CTZ paste (p<0.05). No differences were detected for cinnamaldehyde, terpineol+cinnamaldehyde and chlorhexidine pastes (p>0.05). Conclusion: Pastes containing cinnamaldehyde or terpineol+cinnamaldehyde showed antibacterial activity against E. faecalis similar to CTZ paste, with lower solubility.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 32 条
[1]  
Abbaszadegan Abbas, 2016, Iran Endod J, V11, P44, DOI 10.7508/iej.2016.01.009
[2]   Anatomical challenges, electronic working length determination and current developments in root canal preparation of primary molar teeth [J].
Ahmed, H. M. A. .
INTERNATIONAL ENDODONTIC JOURNAL, 2013, 46 (11) :1011-1022
[3]  
Moura LDAD, 2016, J CLIN PEDIATR DENT, V40, P175, DOI 10.17796/1053-4628-40.3.175
[4]   Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity [J].
Barbieri, Ramona ;
Coppo, Erika ;
Marchese, Anna ;
Daglia, Maria ;
Sobarzo-Sanchez, Eduardo ;
Nabavi, Seyed Fazel ;
Nabavi, Seyed Mohammad .
MICROBIOLOGICAL RESEARCH, 2017, 196 :44-68
[5]  
Barja-Fidalgo Fernanda, 2011, ISRN Dent, V2011, P367318, DOI 10.5402/2011/367318
[6]   Investigating The Antimicrobial Activity Of Different Root Canal Filling Pastes In Deciduous Teeth [J].
Basir, Leila ;
Khanehmasjedi, Mashallah ;
Khosravi, Azardokht ;
Ansarifar, Sahameh .
CLINICAL COSMETIC AND INVESTIGATIONAL DENTISTRY, 2019, 11 :321-326
[7]  
Benbelaid Fethi, 2014, Asian Pacific Journal of Tropical Biomedicine, V4, P463, DOI 10.12980/APJTB.4.2014C1203
[8]   Resins-based denture soft lining materials modified by chlorhexidine salt incorporation: An in vitro analysis of antifungal activity, drug release and hardness [J].
Bertolini, Martinna M. ;
Portela, Maristela B. ;
Curvelo, Jose Alexandre R. ;
Soares, Rosangela M. A. ;
Lourenco, Eduardo J. V. ;
Telles, Daniel M. .
DENTAL MATERIALS, 2014, 30 (08) :793-798
[9]  
Bhinge S. D., 2017, Annales Pharmaceutiques Francaises, V75, P349, DOI 10.1016/j.pharma.2017.04.006
[10]   Teething issues: can doxycycline be safely used in young children? [J].
Boast, Alison ;
Curtis, Nigel ;
Gwee, Amanda .
ARCHIVES OF DISEASE IN CHILDHOOD, 2016, 101 (08) :772-774