Encapsulation and selective recognition of molecularly imprinted theophylline and 17ß-estradiol nanoparticles within electrospun polymer nanofibers

被引:76
作者
Chronakis, Ioannis S.
Jakob, Alexandra
Hagstrom, Bengt
Ye, Lei
机构
[1] Swedish Inst Fiber & Polymer REs, IFP Res, SE-43122 Molndal, Sweden
[2] Lund Univ, Ctr Chem & Chem Engn, SE-22100 Lund, Sweden
关键词
D O I
10.1021/la0613880
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17 beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17 beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on PET. The composite nanofibers prepared under these conditions had a well-defined morphology and displayed the best selective target recognition. Our approach of electrospinning-for-molecularly imprinted nanoparticles-encapsulation has unique advantages and opens new application opportunities for molecularly imprinted nanoparticles and electrospun nanofibers.
引用
收藏
页码:8960 / 8965
页数:6
相关论文
共 30 条
  • [1] Biffis A, 2001, MACROMOL CHEM PHYSIC, V202, P163, DOI 10.1002/1521-3935(20010101)202:1<163::AID-MACP163>3.0.CO
  • [2] 2-M
  • [3] Choi KM, 2005, MATER RES SOC SYMP P, V872, P137
  • [4] Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process - A review
    Chronakis, IS
    [J]. JOURNAL OF MATERIALS PROCESSING TECHNOLOGY, 2005, 167 (2-3) : 283 - 293
  • [5] Generation of molecular recognition sites in electrospun polymer nanofibers via molecular imprinting
    Chronakis, IS
    Milosevic, B
    Frenot, A
    Ye, L
    [J]. MACROMOLECULES, 2006, 39 (01) : 357 - 361
  • [6] Controlled deposition of electrospun poly(ethylene oxide) fibers
    Deitzel, JM
    Kleinmeyer, JD
    Hirvonen, JK
    Tan, NCB
    [J]. POLYMER, 2001, 42 (19) : 8163 - 8170
  • [7] Nanoprocessing of polymers: applications in medicine, sensors, catalysis, photonics
    Dersch, R
    Steinhart, M
    Boudriot, U
    Greiner, A
    Wendorff, JH
    [J]. POLYMERS FOR ADVANCED TECHNOLOGIES, 2005, 16 (2-3) : 276 - 282
  • [8] Spinning continuous fibers for nanotechnology
    Dzenis, Y
    [J]. SCIENCE, 2004, 304 (5679) : 1917 - 1919
  • [9] Polymer nanofibers assembled by electrospinning
    Frenot, A
    Chronakis, IS
    [J]. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2003, 8 (01) : 64 - 75
  • [10] Allometric scaling for voltage and current in electrospinning
    He, JH
    Wane, YQ
    [J]. POLYMER, 2004, 45 (19) : 6731 - 6734