Biased Opioid Receptor Ligands: Gain without Pain

被引：11

作者：

Ranjan, Ravi ^{[1
]}

Pandey, Shubhi ^{[1
]}

Shukla, Arun K. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biol Sci & Bioengn, Kanpur 208016, Uttar Pradesh, India

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 04期

基金：

英国惠康基金;

关键词：

DRUG DISCOVERY; DYSPHORIA; PARADIGMS; AGONISTS;

D O I：

10.1016/j.tem.2017.01.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kappa opioid receptor (k-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for k-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.

引用

页码：247 / 249

页数：3

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