Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts

被引：5
作者：
Proszenyák, A
Agai, B
Hegedus, L [1 ]
Faigl, F
机构：
[1] Tech Univ Budapest, Dept Organ Chem Technol, H-1521 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Hungarian Acad Sci, Organ Chem Technol Res Grp, H-1521 Budapest, Hungary
来源：
APPLIED CATALYSIS A-GENERAL | 2004年 / 269卷 / 1-2期
关键词：
heterogeneous catalytic hydrogenation; benzylpyridine; benzylpiperidine; palladium catalyst; rhodium catalyst;
D O I：
10.1016/j.apcata.2004.04.011
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The heterogeneous catalytic hydrogenation of 4-(4-fluorobenzyl)pyridine resulted in 4-(4-fluorobenzyl)piperidine, an important and valuable pharmaceutical intermediate. The effects of solvents, temperature, catalytic metals and amount of catalyst on the conversion and the rate of the hydrogenation were investigated. Among the precious metal catalysts applied, the best result was obtained by using a rhodium on carbon catalyst. Palladium or platinum on carbon also showed high activities. This hydrogenation is a key step in an industrially feasible synthesis developed recently. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：249 / 253
页数：5
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