Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses

被引：33
作者：
Russell, Charles J. [1 ,2 ]
Hurwitz, Julia L. [1 ,2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, Memphis, TN USA
来源：
EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 02期
关键词：
Sendai virus; paramyxovirus; pediatric vaccine; respiratory tract; antibody; T cell; vaccine vector; intranasal; RESPIRATORY SYNCYTIAL VIRUS; AFRICAN-GREEN MONKEYS; M-PROTEIN BINDS; HUMAN PARAINFLUENZA; FUSION PROTEIN; COTTON RATS; NEUTRALIZING ANTIBODY; MEMBRANE-FUSION; B-CELL; PROTECTIVE IMMUNITY;
D O I：
10.1586/14760584.2016.1114418
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human paramyxoviruses are the etiological agents for life-threatening respiratory virus infections of infants and young children. These viruses, including respiratory syncytial virus (RSV), the human parainfluenza viruses (hPIV1-4) and human metapneumovirus (hMPV), are responsible for millions of serious lower respiratory tract infections each year worldwide. There are currently no standard treatments and no licensed vaccines for any of these pathogens. Here we review research with which Sendai virus, a mouse parainfluenza virus type 1, is being advanced as a Jennerian vaccine for hPIV1 and as a backbone for RSV, hMPV and other hPIV vaccines for children.
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页码：189 / 200
页数：12
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