T Helper 9 Cells: A New Player in Immune-Related Diseases

被引：41

作者：

Chen, Jing ^{[1
,2
]}

Guan, Lian ^{[1
,2
]}

Tang, Lin ^{[1
,2
]}

Liu, Shiming ^{[1
,2
]}

Zhou, Ya ^{[3
]}

Chen, Chao ^{[1
,2
]}

He, Zhixu ^{[4
,5
]}

Xu, Lin ^{[1
,2
]}

机构：

[1] Special Key Lab Gene Detect & Therapy Guizhou Pro, Zunyi, Guizhou, Peoples R China

[2] Zunyi Med Univ, Dept Immunol, Zunyi 563003, Guizhou, Peoples R China

[3] Zunyi Med Univ, Dept Med Phys, Zunyi, Guizhou, Peoples R China

[4] Chinese Acad Med Sci, Key Lab Adult Stem Cell Transformat Res, Zunyi, Guizhou, Peoples R China

[5] Zunyi Med Univ, Dept Pediat, Affiliated Hosp, Zunyi, Guizhou, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2019年 / 38卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Th9; cell; tumor; IL-9; inflammation; TRANSCRIPTION FACTOR PU.1; TH9; CELLS; TGF-BETA; ANTITUMOR IMMUNITY; T(H)9 CELLS; DIFFERENTIATION; INTERLEUKIN-9; EXPRESSION; IL-9; INDUCTION;

D O I：

10.1089/dna.2019.4729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The helper T cell 9 (Thelper-9, Th9), as a functional subgroup of CD4(+)T cells, was first discovered in 2008. Th9 cells expressed transcription factor PU.1 and cytokine interleukin-9 (IL-9) characteristically. Recent researches have shown that the differentiation of Th9 cells was coregulated by cytokine transforming growth factor beta, IL-4, and various transcription factors. Th9 cells, as a new player, played an important role in various immune-related diseases, including tumors, inflammatory diseases, parasite infection, and other diseases. In this article, we summarize the related research progress and discuss the possible prospect.

引用

页码：1040 / 1047

页数：8

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