Immune Cell-Stromal Circuitry in Lupus Photosensitivity

被引：15

作者：

Sim, Ji Hyun ^{[1
,2
]}

Ambler, William G. ^{[1
,3
]}

Sollohub, Isabel F. ^{[1
]}

Howlader, Mir J. ^{[1
,4
]}

Li, Thomas M. ^{[1
]}

Lee, Henry J. ^{[5
]}

Lu, Theresa T. ^{[1
,2
,3
]}

机构：

[1] Hosp Special Surg, Autoimmun & Inflammat Program, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Dept Microbiol & Immunol, New York, NY 10065 USA

[3] Hosp Special Surg, Pediat Rheumatol, New York, NY 10021 USA

[4] Weill Cornell Grad Sch Med Sci, Biochem & Struct Biol Cell Biol Dev Biol Mol Biol, New York, NY 10065 USA

[5] Weill Cornell Med Coll, Dept Dermatol, New York, NY 10065 USA

来源：

JOURNAL OF IMMUNOLOGY | 2021年 / 206卷 / 02期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; INDUCED EDEMA FORMATION; CUTANEOUS LUPUS; DENDRITIC CELLS; GENE-EXPRESSION; LYMPHATIC ENDOTHELIUM; ULTRAVIOLET-RADIATION; APOPTOTIC CELLS; CD11C(+) CELLS;

D O I：

10.4049/jimmunol.2000905

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Photosensitivity is a sensitivity to UV radiation (UVR) commonly found in systemic lupus erythematosus (SLE) patients who have cutaneous disease. Upon even ambient UVR exposure, patients can develop inflammatory skin lesions that can reduce the quality of life. Additionally, UVR-exposed skin lesions can be associated with systemic disease flares marked by rising autoantibody titers and worsening kidney disease. Why SLE patients are photosensitive and how skin sensitivity leads to systemic disease flares are not well understood, and treatment options are limited. In recent years, the importance of immune cell-stromal interactions in tissue function and maintenance is being increasingly recognized. In this review, we discuss SLE as an anatomic circuit and review recent findings in the pathogenesis of photosensitivity with a focus on immune cell-stromal circuitry in tissue health and disease.

引用

页码：302 / 309

页数：8

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