Detecting Traces of 17α-Ethinylestradiol in Complex Water Matrices

被引:6
作者
Zagalo, Paulo M. [1 ]
Ribeiro, Paulo A. [1 ]
Raposo, Maria [1 ]
机构
[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Fis, CEFITEC, P-2829516 Caparica, Portugal
关键词
EE2; hormone; impedance; capacitance; loss tangent; electric modulus; sensor; interdigitated electrodes; PCA; layer-by-layer films; SENSING MECHANISM; ASSEMBLED FILMS; ESTRONE; IMPEDANCE; 17-BETA-ESTRADIOL; ETHINYLESTRADIOL; SPECTROSCOPY; COUNTERIONS; ADSORPTION; ESTROGENS;
D O I
10.3390/s20247324
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Hormones have a harmful impact on the environment and their detection in water bodies is an urgent matter. In this work, we present and analyze a sensor device able to detect traces of the synthetic hormone 17 alpha-ethinylestradiol (EE2) below 10(-9) M in media of different complexities, namely, ultrapure, mineral and tap waters. This device consists of solid supports with interdigitated electrodes without and with a polyethylenimine (PEI) and poly (sodium 4-styrenesulfonate) (PSS) layer-by-layer film deposited on it. Device response was evaluated through capacitance, loss tangent and electric modulus spectra and the data were analyzed by principal component analysis method. While the three types of spectra were demonstrated to be able to clearly discriminate the different media, loss tangent spectra allow for the detection of EE2 concentration, with a sensitivity of -0.072 +/- 0.009 and -0.44 +/- 0.03 per decade of concentration, for mineral and tap water, respectively. Detection limits values were found to be lower than the ones present in the literature and presenting values of 8.6 fM (2.6 pg/L) and of 7.5 fM (22.2 pg/L) for tap and mineral waters, respectively. Moreover, the obtained response values follow the same behavior with EE2 concentration in any medium, meaning that loss tangent spectra allow the quantification of EE2 concentration in aqueous complex matrices.
引用
收藏
页码:1 / 14
页数:14
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