Microglial phagocytosis of live neurons

被引：675

作者：

Brown, Guy C. ^{[1
]}

Neher, Jonas J. ^{[2
,3
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[2] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Cellular Neurol, D-72076 Tubingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 04期

基金：

英国惠康基金;

关键词：

CELL-DEATH; PHOSPHATIDYLSERINE EXTERNALIZATION; ACTIVATED MICROGLIA; VIABLE NEURONS; EAT-ME; ENGULFMENT; PROTEIN; NEUROTOXICITY; MODEL; INHIBITION;

D O I：

10.1038/nrn3710

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons - a process that we have termed phagoptosis. In this Progress article, we discuss evidence suggesting that phagoptosis may contribute to neuronal loss during brain development, inflammation, ischaemia and neurodegeneration.

引用

页码：209 / 216

页数：8

共 76 条

[1]

Bal-Price A, 2001, J NEUROSCI, V21, P6480

[2] ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo [J].

Barcia, Carlos ;

Maria Ros, Carmen ;

Annese, Valentina ;

Carrillo-de Sauvage, Maria Angeles ;

Ros-Bernal, Francisco ;

Gomez, Aurora ;

Enrique Yuste, Jose ;

Maria Campuzano, Carmen ;

de Pablos, Vicente ;

Fernandez-Villalba, Emiliano ;

Trinidad Herrero, Maria .

SCIENTIFIC REPORTS, 2012, 2

[3] Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3 [J].

Berg, Alexander ;

Zelano, Johan ;

Stephan, Alexander ;

Thams, Sebastian ;

Barres, Ben A. ;

Pekny, Milos ;

Pekna, Marcela ;

Cullheim, Staffan .

EXPERIMENTAL NEUROLOGY, 2012, 237 (01) :8-17

[4] Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination [J].

Binder, Michele D. ;

Cate, Holly S. ;

Prieto, Anne L. ;

Kemper, Dennis ;

Butzkueven, Helmut ;

Gresle, Melissa M. ;

Cipriani, Tania ;

Jokubaitis, Vilija G. ;

Carmeliet, Peter ;

Kilpatrick, Trevor J. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (20) :5195-5206

[5] Microglia-mediated neurotoxicity: uncovering the molecular mechanisms [J].

Block, Michelle L. ;

Zecca, Luigi ;

Hong, Jau-Shyong .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (01) :57-69

[6] Eaten alive! Cell death by primary phagocytosis: 'phagoptosis' [J].

Brown, Guy C. ;

Neher, Jonas J. .

TRENDS IN BIOCHEMICAL SCIENCES, 2012, 37 (08) :325-332

[7] Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons [J].

Brown, Guy C. ;

Neher, Jonas J. .

MOLECULAR NEUROBIOLOGY, 2010, 41 (2-3) :242-247

[8] Tubby regulates microglial phagocytosis through MerTK [J].

Caberoy, Nora B. ;

Alvarado, Gabriela ;

Li, Wei .

JOURNAL OF NEUROIMMUNOLOGY, 2012, 252 (1-2) :40-48

[9] Galectin-3 is a new MerTK-specific eat-me signal [J].

Caberoy, Nora B. ;

Alvarado, Gabriela ;

Bigcas, Jo-Lawrence ;

Li, Wei .

JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (02) :401-407

[10] Control of microglial neurotoxicity by the fractalkine receptor [J].

Cardona, Astrid E. ;

Pioro, Erik P. ;

Sasse, Margaret E. ;

Kostenko, Volodymyr ;

Cardona, Sandra M. ;

Dijkstra, Ineke M. ;

Huang, DeRen ;

Kidd, Grahame ;

Dombrowski, Stephen ;

Dutta, RanJan ;

Lee, Jar-Chi ;

Cook, Donald N. ;

Jung, Steffen ;

Lira, Sergio A. ;

Littman, Dan R. ;

Ransohoff, Richard M. .

NATURE NEUROSCIENCE, 2006, 9 (07) :917-924

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