The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action

被引:28
作者
Matsumura, Yukiko [1 ]
Yokoyama, Yoshihito [1 ]
Hirakawa, Hachidai [1 ]
Shigeto, Tatsuhiko [1 ]
Futagami, Masayuki [1 ]
Mizunuma, Hideki [1 ]
机构
[1] Hirosaki Grad Sch Med, Dept Obstet & Gynecol, Hirosaki, Aomori 0368562, Japan
来源
MOLECULAR PAIN | 2014年 / 10卷
关键词
Paclitaxel; Goshajinkigan; Peripheral neuropathy; Degeneration of the ganglion cells; TRPV4; GOSHA-JINKI-GAN; RECEPTOR POTENTIAL VANILLOID-4; CLINICAL-PRACTICE GUIDELINE; MICE LACKING TRPV4; HERBAL MEDICINE; OVARIAN-CANCER; CHANNELS; HYPERALGESIA; CHEMOTHERAPY; MULTICENTER;
D O I
10.1186/1744-8069-10-61
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: This study aimed to evaluate the prophylactic effect of goshajinkigan (GJG) on paclitaxel (PTX)-induced neuropathy and to elucidate the mechanism of action. Results: There was a time-dependent irreversible decrease in pain threshold in PTX group. In PTX/GJG group, pain threshold showed changes in the same level as control. Electron microscope showed that although the ganglion cells of control and PTX/GJG groups were normal, degeneration of the nucleus and swelling of the mitochondria were observed in PTX group. Expression of transient receptor potential vanilloid 4 (TRPV4) gene in PTX group significantly increased compared with that in control and PTX/GJG groups. In TRPV4 knock-out mice, no PTX-induced hyperalgesia was observed, and there was no significant difference in pain threshold between the 3 groups. Conclusions: These results showed that PTX induced hyperalgesia by enhancing TRPV4 expression, and suggested that GJG might alleviate hyperalgesia by preventing degeneration of the ganglion cells and suppressing TRPV4 expression.
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页数:8
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共 39 条
[21]   Identification of a cold receptor reveals a general role for TRP channels in thermosensation [J].
McKemy, DD ;
Neuhausser, WM ;
Julius, D .
NATURE, 2002, 416 (6876) :52-58
[22]   Impaired osmotic sensation in mice lacking TRPV4 [J].
Mizuno, A ;
Matsumoto, N ;
Imai, M ;
Suzuki, M .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 285 (01) :C96-C101
[23]   Efficacy of lafutidine, a histamine H2-receptor antagonist, for taxane-induced peripheral neuropathy in patients with gynecological malignancies [J].
Nagano, Hiroaki ;
Sanai, Hideomi ;
Muraoka, Mitsue ;
Takagi, Koichiro .
GYNECOLOGIC ONCOLOGY, 2012, 127 (01) :172-174
[24]   GOSHA-JINKI-GAN (HERBAL MEDICINE) IN STREPTOZOCIN-INDUCED DIABETIC NEUROPATHY [J].
NISHIZAWA, M ;
SUTHERLAND, WHF ;
NUKADA, H .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 132 (02) :177-181
[25]   ANTIOXIDANT ACTION OF NATURAL HEALTH PRODUCTS AND CHINESE HERBS [J].
NIWA, Y ;
MIYACHI, Y .
INFLAMMATION, 1986, 10 (01) :79-91
[26]   STRUCTURE OF TUBULIN AT 6.5 ANGSTROM AND LOCATION OF THE TAXOL-BINDING SITE [J].
NOGALES, E ;
WOLF, SG ;
KHAN, IA ;
LUDUENA, RF ;
DOWNING, KH .
NATURE, 1995, 375 (6530) :424-427
[27]   Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: A Gynecologic Oncology Group study [J].
Ozols, RF ;
Bundy, BN ;
Greer, BE ;
Fowler, JM ;
Clarke-Pearson, D ;
Burger, RA ;
Mannel, RS ;
DeGeest, K ;
Hartenbach, EM ;
Baergen, R .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (17) :3194-3200
[28]   Resistance to paclitaxel is proportional to cellular total antioxidant capacity [J].
Ramanathan, B ;
Jan, KY ;
Chen, CH ;
Hour, TC ;
Yu, HJ ;
Pu, YS .
CANCER RESEARCH, 2005, 65 (18) :8455-8460
[29]   Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients [J].
Satoh, Hiroyasu .
JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2013, 11 (01) :11-16
[30]   2006 update of recommendations for the use of white blood cell growth factors: An evidence-based clinical practice guideline [J].
Smith, Thomas J. ;
Khatcheressian, James ;
Lyman, Gary H. ;
Ozer, Howard ;
Armitage, James O. ;
Balducci, Lodovico ;
Bennett, Charles L. ;
Cantor, Scott B. ;
Crawford, Jeffrey ;
Cross, Scott J. ;
Demetri, George ;
Desch, Christopher E. ;
Pizzo, Philip A. ;
Schiffer, Charles A. ;
Schwartzberg, Lee ;
Somerfield, Mark R. ;
Somlo, George ;
Wade, James C. ;
Wade, James L. ;
Winn, Rodger J. ;
Wozniak, Antoinette J. ;
Wolff, Antonio C. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (19) :3187-3205