Role of microRNA-regulated cancer stem cells in recurrent hepatocellular carcinoma

被引：7
作者：
Li, Lei [1 ]
Xun, Chen [2 ]
Yu, Chun-Hong [3 ,4 ]
机构：
[1] Univ Otago, Dept Pathol, Dunedin 9016, New Zealand
[2] Zhuzhou Cent Hosp, Dept Hepatobiliary Surg, Zhuzhou 412000, Hunan, Peoples R China
[3] Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China
[4] Beihang Univ, Sch Engn Med, 37 Xueyuan Rd, Beijing 100191, Peoples R China
来源：
WORLD JOURNAL OF HEPATOLOGY | 2022年 / 14卷 / 12期
关键词：
Hepatocellular carcinoma; Cancer stem cells; MicroRNAs; Recurrence; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; SELF-RENEWAL; SORAFENIB RESISTANCE; THERAPEUTIC TARGET; LIVER; EXPRESSION; METASTASIS; EPCAM; MIGRATION;
D O I：
10.4254/wjh.v14.i12.1985
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Among the most common cancers, hepatocellular carcinoma (HCC) has a high rate of tumor recurrence, tumor dormancy, and drug resistance after initial successful chemotherapy or radiotherapy. A small subset of cancer cells, cancer stem cells (CSCs), exhibit stem cell characteristics and are present in various cancers, including HCC. The dysregulation of microRNAs (miRNAs) often accompanies the occurrence and development of HCC. miRNAs can influence tumorigenesis, progression, recurrence, and drug resistance by regulating CSCs properties, which supports their clinical utility in managing and treating HCC. This review summarizes the regulatory effects of miRNAs on CSCs in HCC with a special focus on their impact on HCC recurrence.
引用
收藏
页码：1985 / 1996
页数：12
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