Subcellular compartmentation of ascorbate and its variation in disease states

被引：56

作者：

Banhegyi, Gabor ^{[1
]}

Benedetti, Angelo ^{[2
]}

Margittai, Eva ^{[3
,4
]}

Marcolongo, Paola ^{[2
]}

Fulceri, Rosella ^{[2
]}

Nemeth, Csilla E. ^{[1
]}

Szarka, Andras ^{[5
,6
]}

机构：

[1] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochemistry, H-1444 Budapest, Hungary

[2] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy

[3] Semmelweis Univ, Inst Human Physiol, H-1085 Budapest, Hungary

[4] Semmelweis Univ, Clin Expt Res, H-1085 Budapest, Hungary

[5] Hungarian Acad Sci, Pathobiochem Res Grp, Budapest, Hungary

[6] Budapest Univ Technol & Econ, Dept Appl Biotechnol & Food Sci, Lab Biochem & Mol Biol, Budapest, Hungary

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 09期

基金：

匈牙利科学研究基金会;

关键词：

Ascorbate; Dehydroascorbic acid; Compartmentation; Scurvy; Arterial tortuosity syndrome; GLUT; VITAMIN-C; DEHYDROASCORBIC ACID; GLUCOSE-TRANSPORTER; GENE-EXPRESSION; NEURONAL DIFFERENTIATION; GULONOLACTONE OXIDASE; CELL-PROLIFERATION; COLLAGEN-SYNTHESIS; DNA DEMETHYLATION; NUCLEAR-ENVELOPE;

D O I：

10.1016/j.bbamcr.2014.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beyond its general role as antioxidant, specific functions of ascorbate are compartmentalized within the eukaryotic cell. The list of organelle-specific functions of ascorbate has been recently expanded with the epigenetic role exerted as a cofactor for DNA and histone demethylases in the nucleus. Compartmentation necessitates the transport through intracellular membranes; members of the GLUT family and sodium-vitamin C cotransporters mediate the permeation of dehydroascorbic acid and ascorbate, respectively. Recent observations show that increased consumption and/or hindered entrance of ascorbate in/to a compartment results in pathological alterations partially resembling to scurvy, thus diseases of ascorbate compartmentation can exist. The review focuses on the reactions and transporters that can modulate ascorbate concentration and redox state in three compartments: endoplasmic reticulum, mitochondria and nucleus. By introducing the relevant experimental and clinical findings we make an attempt to coin the term of ascorbate compartmentation disease. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1909 / 1916

页数：8

共 112 条

[51] Mitochondrial uptake and recycling of ascorbic acid [J].

Li, X ;

Cobb, CE ;

Hill, KE ;

Burk, RF ;

May, JM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2001, 387 (01) :143-153

[52] Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma [J].

Lian, Christine Guo ;

Xu, Yufei ;

Ceol, Craig ;

Wu, Feizhen ;

Larson, Allison ;

Dresser, Karen ;

Xu, Wenqi ;

Tan, Li ;

Hu, Yeguang ;

Zhan, Qian ;

Lee, Chung-wei ;

Hu, Di ;

Lian, Bill Q. ;

Kleffel, Sonja ;

Yang, Yijun ;

Neiswender, James ;

Khorasani, Abraham J. ;

Fang, Rui ;

Lezcano, Cecilia ;

Duncan, Lyn M. ;

Scolyer, Richard A. ;

Thompson, John F. ;

Kakavand, Hojabr ;

Houvras, Yariv ;

Zon, Leonard I. ;

Mihm, Martin C., Jr. ;

Kaiser, Ursula B. ;

Schatton, Tobias ;

Woda, Bruce A. ;

Murphy, George F. ;

Shi, Yujiang G. .

CELL, 2012, 150 (06) :1135-1146

[53] Expanding chemical biology of 2-oxoglutarate oxygenases [J].

Loenarz, Christoph ;

Schofield, Christopher J. .

NATURE CHEMICAL BIOLOGY, 2008, 4 (03) :152-156

[54] ASCORBATE STIMULATION OF PAT CELLS CAUSES AN INCREASE IN TRANSCRIPTION RATES AND A DECREASE IN DEGRADATION RATES OF PROCOLLAGEN MESSENGER-RNA [J].

LYONS, BL ;

SCHWARZ, RI .

NUCLEIC ACIDS RESEARCH, 1984, 12 (05) :2569-2579

[55] Type-2 copper-containing enzymes [J].

MacPherson, I. S. ;

Murphy, M. E. P. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2007, 64 (22) :2887-2899

[56] Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine POTENTIAL IMPLICATIONS FOR ACTIVE DEMETHYLATION OF CpG SITES [J].

Maiti, Atanu ;

Drohat, Alexander C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (41) :35334-35338

[57] Vitamin C: update on physiology and pharmacology [J].

Mandl, J. ;

Szarka, A. ;

Banhegyi, G. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 157 (07) :1097-1110

[58] The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter [J].

Mardones, Lorena ;

Ormazabal, Valeska ;

Romo, Ximena ;

Jana, Claudia ;

Binder, Pablo ;

Pena, Eduardo ;

Vergara, Marilyn ;

Zuniga, Felipe A. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 410 (01) :7-12

[59] Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of guinea pigs [J].

Margittai, É ;

Bánhegyi, G ;

Kiss, A ;

Nagy, G ;

Mandl, J ;

Schaff, Z ;

Csala, M .

JOURNAL OF NUTRITION, 2005, 135 (11) :2530-2534

[60] Production of H2O2 in the Endoplasmic Reticulum Promotes In Vivo Disulfide Bond Formation [J].

Margittai, Eva ;

Loew, Peter ;

Stiller, Ibolya ;

Greco, Alessandra ;

Garcia-Manteiga, Jose Manuel ;

Pengo, Niccolo ;

Benedetti, Angelo ;

Sitia, Roberto ;

Banhegyi, Gabor .

ANTIOXIDANTS & REDOX SIGNALING, 2012, 16 (10) :1088-1099

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