ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation

被引：55

作者：

Arshad, Rabia ^{[1
]}

Sohail, Muhammad Farhan ^{[1
,2
]}

Sarwar, Hafiz Shoaib ^{[1
,2
]}

Saeed, Hamid ^{[3
]}

Ali, Imran ^{[4
]}

Akhtar, Sohail ^{[5
]}

Hussain, Syed Zajif ^{[6
]}

Afzal, Iqra ^{[1
]}

Jahan, Sarwat ^{[7
]}

Anees-ur-Rehman ^{[1
,8
]}

Shahnaz, Gul ^{[1
]}

机构：

[1] Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad, Pakistan

[2] Riphah Int Univ, RIPS, Lahore Campus, Lahore, Pakistan

[3] Univ Punjab, Univ Coll Pharm, Lahore, Pakistan

[4] Islamia Univ, Univ Coll Agr & Environm Sci, Dept Entomol, Bahawalpur, Pakistan

[5] Victoria Hosp, Bahawalpur, Pakistan

[6] LUMS, SBA SSE, Dept Chem & Chem Engn, Lahore, Pakistan

[7] Quaid I Azam Univ, Dept Anim Sci, Islamabad, Pakistan

[8] USM, Sch Pharmaceut Sci, George Town, Malaysia

来源：

PLOS ONE | 2019年 / 14卷 / 06期

关键词：

RISK-FACTORS; CHITOSAN NANOPARTICLES; DRUG-RELEASE; MECHANISMS; POLYMERS; MUCIN;

D O I：

10.1371/journal.pone.0217079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive and negative controls. Over all, thiolated bandage showed potential as an advanced therapeutic agent for treating surgical site infections, meeting the required features of an ideal surgical dressing.

引用

页数：18

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