Epidermal growth factor receptor tyrosine kinase inhibitors in elderly or poor performance status patients with advanced non-small cell lung cancer

被引：20
作者：
Lin, Chia-Chi [1 ]
Yang, Chih-Hsin [1 ]
机构：
[1] Natl Taiwan Univ Hosp, Dept Oncol, Taipei 10002, Taiwan
来源：
TARGETED ONCOLOGY | 2009年 / 4卷 / 01期
关键词：
Epidermal growth factor receptor; Erlotinib; Gefitinib; Non-small cell lung cancer; Tyrosine kinase inhibitor; PHASE-II TRIAL; CHEMOTHERAPY-NAIVE PATIENTS; GEFITINIB ANTITUMOR-ACTIVITY; PACLITAXEL PLUS CARBOPLATIN; SUPPORTIVE CARE; GEMCITABINE PLUS; IRREVERSIBLE INHIBITOR; ACQUIRED-RESISTANCE; RANDOMIZED-TRIAL; EGFR MUTATIONS;
D O I：
10.1007/s11523-009-0104-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elderly and poor performance status advanced non-small cell lung cancer (NSCLC) patients often tolerate chemotherapy poorly. Special approaches are needed for these patient populations. Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR), erlotinib and gefitinib, are active agents in the treatment of advanced NSCLC. Several phase II trials have been conducted utilizing EGFR TKIs in elderly or poor performance status patients with advanced NSCLC. This review will summarize the results of erlotinib or gefitinib in these subsets of patients with advanced NSCLC.
引用
收藏
页码：37 / 44
页数：8
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