Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins

被引：30

作者：

Fetter, Lisa ^{[1
]}

Richards, Jonathan ^{[1
]}

Daniel, Jessica ^{[1
]}

Roon, Laura ^{[1
]}

Rowland, Teisha J. ^{[2
,3
]}

Bonham, Andrew J. ^{[1
]}

机构：

[1] Metropolitan State Univ Denver, Dept Chem, Denver, CO 80204 USA

[2] Univ Colorado, Cardiovasc Inst, Aurora, CO 80045 USA

[3] Univ Colorado, Adult Med Genet Program, Aurora, CO 80045 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 82期

关键词：

GENERATION; SELECTION; BINDING; BLOOD;

D O I：

10.1039/c5cc05933j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.

引用

页码：15137 / 15140

页数：4

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