Hippocampal shape analysis in Alzheimer's disease using functional data analysis

被引：19

作者：

Epifanio, Irene ^{[1
]}

Ventura-Campos, Noelia ^{[2
]}

机构：

[1] Univ Jaume 1, Dept Matemat, Castellon de La Plana 12071, Spain

[2] Univ Jaume 1, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana 12071, Spain

来源：

STATISTICS IN MEDICINE | 2014年 / 33卷 / 05期

关键词：

functional data analysis; shape analysis; Alzheimer's disease; principal component analysis; independent component analysis; discriminant analysis; MILD COGNITIVE IMPAIRMENT; MULTILAYER PERCEPTRON; CLASSIFICATION; SURFACES; VOLUME; ALGORITHMS; FEATURES;

D O I：

10.1002/sim.5968

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hippocampus is one of the first affected regions in Alzheimer's disease. The left hippocampi of control subjects, patients with mild cognitive impairment and patients with Alzheimer's disease are represented by spherical harmonics. Functional data analysis is used in the hippocampal shape analysis. Functional principal component analysis and functional independent component analysis are defined for multivariate functions with two arguments. A functional linear discriminant function is also defined. Comparisons with other approaches are carried out. Our functional approach gives promising results, especially in shape classification. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：867 / 880

页数：14

共 54 条

[31]

Li Shen, 2004, Intelligent Data Analysis, V8, P519

[32] Estimating the intensity of ward admission and its effect on emergency department access block [J].

Luo, Wei ;

Cao, Jiguo ;

Gallagher, Marcus ;

Wiles, Janet .

STATISTICS IN MEDICINE, 2013, 32 (15) :2681-2694

[33] Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI [J].

MacDonald, D ;

Kabani, N ;

Avis, D ;

Evans, AC .

NEUROIMAGE, 2000, 12 (03) :340-356

[34] Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI [J].

Mueller, Matthias J. ;

Greverus, Dirk ;

Weibrich, Carsten ;

Dellani, Paulo Roberto ;

Scheurich, Armin ;

Stoeter, Peter ;

Fellgiebel, Andreas .

NEUROBIOLOGY OF AGING, 2007, 28 (03) :398-403

[35]

Mungas D., 2001, Neurology, V57, P2229

[36] Statistical shape analysis of brain structures using spherical wavelets [J].

Nain, D. ;

Stynen, M. ;

Niethammer, M. ;

Levitt, J. J. ;

Shenton, M. E. ;

Gerig, G. ;

Bobick, A. ;

Tannenbaum, A. .

2007 4TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING : MACRO TO NANO, VOLS 1-3, 2007, :209-+

[37] Statistical analysis of twin populations using dissimilarity measurements in hippocampus shape space [J].

Park, Youngser ;

Priebe, Carey E. ;

Miller, Michael I. ;

Mohan, Nikhil R. ;

Botteron, Kelly N. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2008,

[38] Mild cognitive impairment as a diagnostic entity [J].

Petersen, RC .

JOURNAL OF INTERNAL MEDICINE, 2004, 256 (03) :183-194

[39]

Ramsay J., 2005, FUNCTIONAL DATA ANAL, VSecond

[40]

Ramsay J. O., 2002, Applied functional data analysis: methods and case studies, V77

← 1 2 3 4 5 6 →